Membranous obliterative bronchitis: A proposed unifying model

Andrew Colin, Theofanis Tsiligiannis, Vânia Nosé, David A. Waltz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Three adults with cystic fibrosis (one after lung transplantation) presented with fever, chest pain, and acute radiographic changes. The changes included a cavitary lesion of the lung, acute dense infiltrates, and lobar collapse. After failing conventional antibiotic therapy, the patients underwent flexible bronchoscopy. All had bronchial obstruction by a membrane that had completely occluded the bronchial orifice at the bifurcation of the bronchi. Therapeutic interventions ranged from continuing intravenous antibiotics, bronchoscopy-assisted perforation of the membrane by sharp instrumentation, and transthoracic needle-guided perforation of the membrane with subsequent stenting of the orifice. The patients recovered, but the posttransplant patient had recurrent membranous obstructions with multiple interventions. The cause and triggers of the process are unknown. Based on repeated observations of the evolution of the membranes, and histologic material from bronchoscopies, we propose a putative paradigm of the natural history of the process. We suggest that local stimuli generate a richly vascularized granulation polyp, which progresses in a "shutter-like" motion to form partial or completely obstructive membranes. The subsequent course depends on the vascular supply to the membrane. We also propose that similar processes may be the underlying pathologic events in some cases of lung abscess and necrotizing pneumonia.

Original languageEnglish
Pages (from-to)126-132
Number of pages7
JournalPediatric Pulmonology
Volume41
Issue number2
DOIs
StatePublished - Feb 1 2006

Fingerprint

Bronchitis
Membranes
Bronchoscopy
Anti-Bacterial Agents
Lung Abscess
Lung Transplantation
Bronchi
Polyps
Natural History
Chest Pain
Cystic Fibrosis
Needles
Blood Vessels
Fever
Lung
Therapeutics

Keywords

  • Bronchitis obliterans
  • Cystic fibrosis
  • Obliterative bronchitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Colin, A., Tsiligiannis, T., Nosé, V., & Waltz, D. A. (2006). Membranous obliterative bronchitis: A proposed unifying model. Pediatric Pulmonology, 41(2), 126-132. https://doi.org/10.1002/ppul.20348

Membranous obliterative bronchitis : A proposed unifying model. / Colin, Andrew; Tsiligiannis, Theofanis; Nosé, Vânia; Waltz, David A.

In: Pediatric Pulmonology, Vol. 41, No. 2, 01.02.2006, p. 126-132.

Research output: Contribution to journalArticle

Colin, A, Tsiligiannis, T, Nosé, V & Waltz, DA 2006, 'Membranous obliterative bronchitis: A proposed unifying model', Pediatric Pulmonology, vol. 41, no. 2, pp. 126-132. https://doi.org/10.1002/ppul.20348
Colin, Andrew ; Tsiligiannis, Theofanis ; Nosé, Vânia ; Waltz, David A. / Membranous obliterative bronchitis : A proposed unifying model. In: Pediatric Pulmonology. 2006 ; Vol. 41, No. 2. pp. 126-132.
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