Abstract
Objectives: To examine erythrocyte membrane functions in mood disorder patients and to establish possible diagnostic marker parameter(s). Design: Collection of blood samples from mood disorder patients and age-matched control volunteers. Preparation of erythrocyte membranes for the proposed studies. Setting: Out patients/in patients, psychiatry ward, Civil Hospital, Ahmedabad, Gujarat, India, Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Vadodara, Gujarat, India. Subjects: Unipolar and bipolar subjects. Control subjects (randomly selected volunteers). Results: The most significant results were a duration dependent decrease in the TPL/CHL ratio (mole:mole),changes in both the substrate and temperature kinetics properties of AChE and elevated plasma BChE activity in the mood disorder patients. Conclusion: The results suggest that the altered lipid profiles and the TPL/CHL (mole: mole) ratio and the altered temperature-dependent activity coefficients of erythrocyte membrane AChE and elevated plasma BChE activities could serve as useful diagnostic pointers for mood disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 11-20 |
| Number of pages | 10 |
| Journal | South African Psychiatry Review |
| Volume | 6 |
| Issue number | 1 |
| State | Published - Feb 1 2003 |
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Keywords
- Erythrocytes
- Membrane function
- Mood disorder
ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Membrane function alterations in erythrocytes from mood disorder patients. / Katewa, Subhash D.; Dave, Kunjan R; Katyare, Surendra S.
In: South African Psychiatry Review, Vol. 6, No. 1, 01.02.2003, p. 11-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Membrane function alterations in erythrocytes from mood disorder patients
AU - Katewa, Subhash D.
AU - Dave, Kunjan R
AU - Katyare, Surendra S.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Objectives: To examine erythrocyte membrane functions in mood disorder patients and to establish possible diagnostic marker parameter(s). Design: Collection of blood samples from mood disorder patients and age-matched control volunteers. Preparation of erythrocyte membranes for the proposed studies. Setting: Out patients/in patients, psychiatry ward, Civil Hospital, Ahmedabad, Gujarat, India, Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Vadodara, Gujarat, India. Subjects: Unipolar and bipolar subjects. Control subjects (randomly selected volunteers). Results: The most significant results were a duration dependent decrease in the TPL/CHL ratio (mole:mole),changes in both the substrate and temperature kinetics properties of AChE and elevated plasma BChE activity in the mood disorder patients. Conclusion: The results suggest that the altered lipid profiles and the TPL/CHL (mole: mole) ratio and the altered temperature-dependent activity coefficients of erythrocyte membrane AChE and elevated plasma BChE activities could serve as useful diagnostic pointers for mood disorders.
AB - Objectives: To examine erythrocyte membrane functions in mood disorder patients and to establish possible diagnostic marker parameter(s). Design: Collection of blood samples from mood disorder patients and age-matched control volunteers. Preparation of erythrocyte membranes for the proposed studies. Setting: Out patients/in patients, psychiatry ward, Civil Hospital, Ahmedabad, Gujarat, India, Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Vadodara, Gujarat, India. Subjects: Unipolar and bipolar subjects. Control subjects (randomly selected volunteers). Results: The most significant results were a duration dependent decrease in the TPL/CHL ratio (mole:mole),changes in both the substrate and temperature kinetics properties of AChE and elevated plasma BChE activity in the mood disorder patients. Conclusion: The results suggest that the altered lipid profiles and the TPL/CHL (mole: mole) ratio and the altered temperature-dependent activity coefficients of erythrocyte membrane AChE and elevated plasma BChE activities could serve as useful diagnostic pointers for mood disorders.
KW - Erythrocytes
KW - Membrane function
KW - Mood disorder
UR - http://www.scopus.com/inward/record.url?scp=0348219288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0348219288&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0348219288
VL - 6
SP - 11
EP - 20
JO - South African Psychiatry Review
JF - South African Psychiatry Review
SN - 1994-8220
IS - 1
ER -