Membrane function alterations in erythrocytes from mood disorder patients

Subhash D. Katewa, Kunjan R. Dave, Surendra S. Katyare

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objectives: To examine erythrocyte membrane functions in mood disorder patients and to establish possible diagnostic marker parameter(s). Design: Collection of blood samples from mood disorder patients and age-matched control volunteers. Preparation of erythrocyte membranes for the proposed studies. Setting: Out patients/in patients, psychiatry ward, Civil Hospital, Ahmedabad, Gujarat, India, Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Vadodara, Gujarat, India. Subjects: Unipolar and bipolar subjects. Control subjects (randomly selected volunteers). Results: The most significant results were a duration dependent decrease in the TPL/CHL ratio (mole:mole),changes in both the substrate and temperature kinetics properties of AChE and elevated plasma BChE activity in the mood disorder patients. Conclusion: The results suggest that the altered lipid profiles and the TPL/CHL (mole: mole) ratio and the altered temperature-dependent activity coefficients of erythrocyte membrane AChE and elevated plasma BChE activities could serve as useful diagnostic pointers for mood disorders.

Original languageEnglish (US)
Pages (from-to)11-20
Number of pages10
JournalSouth African Psychiatry Review
Volume6
Issue number1
StatePublished - Feb 1 2003

Keywords

  • Erythrocytes
  • Membrane function
  • Mood disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health

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