Membrane attack by complement

Eckhard R. Podack, Jurg Tschopp

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Membrane attack by complement involves the self-assembly on membranes of five hydrophilic proteins (C5b, C6, C7, C8 and C9) to an amphiphilic tubular complex comprising approximately 20 subunits. The hydrophilic-amphiphilic transition of the precursor proteins is achieved by restricted unfolding and exposure of previously hidden hydrophobic domains. Restricted unfolding, in turn, is driven by high-affinity protein-protein interactions resulting in the formation of amphilic complexes. Circular polymerization of C9 to a tubular complex (poly C9) constitutes the molecular mechanism for transmembrane channel assembly and formation of ultrastructural membrane lesions.

Original languageEnglish
Pages (from-to)589-603
Number of pages15
JournalMolecular Immunology
Volume21
Issue number7
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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Membranes
Proteins
Protein Precursors
Polymerization
complement C9 polymer

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Membrane attack by complement. / Podack, Eckhard R.; Tschopp, Jurg.

In: Molecular Immunology, Vol. 21, No. 7, 01.01.1984, p. 589-603.

Research output: Contribution to journalArticle

Podack, ER & Tschopp, J 1984, 'Membrane attack by complement', Molecular Immunology, vol. 21, no. 7, pp. 589-603. https://doi.org/10.1016/0161-5890(84)90044-0
Podack, Eckhard R. ; Tschopp, Jurg. / Membrane attack by complement. In: Molecular Immunology. 1984 ; Vol. 21, No. 7. pp. 589-603.
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