TY - JOUR
T1 - Membrane attack by complement
AU - Podack, Eckhard R.
AU - Tschopp, Jurg
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1984/7
Y1 - 1984/7
N2 - Membrane attack by complement involves the self-assembly on membranes of five hydrophilic proteins (C5b, C6, C7, C8 and C9) to an amphiphilic tubular complex comprising approximately 20 subunits. The hydrophilic-amphiphilic transition of the precursor proteins is achieved by restricted unfolding and exposure of previously hidden hydrophobic domains. Restricted unfolding, in turn, is driven by high-affinity protein-protein interactions resulting in the formation of amphilic complexes. Circular polymerization of C9 to a tubular complex (poly C9) constitutes the molecular mechanism for transmembrane channel assembly and formation of ultrastructural membrane lesions.
AB - Membrane attack by complement involves the self-assembly on membranes of five hydrophilic proteins (C5b, C6, C7, C8 and C9) to an amphiphilic tubular complex comprising approximately 20 subunits. The hydrophilic-amphiphilic transition of the precursor proteins is achieved by restricted unfolding and exposure of previously hidden hydrophobic domains. Restricted unfolding, in turn, is driven by high-affinity protein-protein interactions resulting in the formation of amphilic complexes. Circular polymerization of C9 to a tubular complex (poly C9) constitutes the molecular mechanism for transmembrane channel assembly and formation of ultrastructural membrane lesions.
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U2 - 10.1016/0161-5890(84)90044-0
DO - 10.1016/0161-5890(84)90044-0
M3 - Article
C2 - 6379417
AN - SCOPUS:0021256194
VL - 21
SP - 589
EP - 603
JO - Molecular Immunology
JF - Molecular Immunology
SN - 0161-5890
IS - 7
ER -