Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep

Suzanne E. Goldman, Karen W. Adkins, M. Wade Calcutt, Melissa D. Carter, Robert L. Goodpaste, Lily Wang, Yaping Shi, Helen J. Burgess, David L. Hachey, Beth A. Malow

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (Cmax) and time to peak concentration (Tmax) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin.

Original languageEnglish (US)
Pages (from-to)2525-2535
Number of pages11
JournalJournal of Autism and Developmental Disorders
Volume44
Issue number10
DOIs
StatePublished - 2014

Keywords

  • Dim light melatonin onset
  • Insomnia
  • N-acetylserotonin

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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    Goldman, S. E., Adkins, K. W., Calcutt, M. W., Carter, M. D., Goodpaste, R. L., Wang, L., Shi, Y., Burgess, H. J., Hachey, D. L., & Malow, B. A. (2014). Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep. Journal of Autism and Developmental Disorders, 44(10), 2525-2535. https://doi.org/10.1007/s10803-014-2123-9