Abstract
Melatonin, the main hormone of the pineal gland, when chronically injected into young mice or mice immuno-depressed by aging or by cyclophosphamide treatment, is able to enhance the antibody response to a T-dependent antigen. The enhancement of the antibody response is associated with increased induction of T helper cell activity and IL-2 production, as evidenced in mice immunodepressed by aging or by cyclophosphamide treatment. These observations suggest that melatonin treatment may be successfully used in the therapy of immunodepressive conditions.
Original language | English (US) |
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Pages (from-to) | 81-89 |
Number of pages | 9 |
Journal | Immunopharmacology |
Volume | 23 |
Issue number | 2 |
DOIs | |
State | Published - Mar 4 1992 |
Externally published | Yes |
Keywords
- Antibody
- IL-2
- Immunodeficiency
- Melatonin
- T cell
ASJC Scopus subject areas
- Pharmacology