Melatonin as immunompdulator in immunodeficient mice

M. Cristina Caroleo; Daniela Frasca; Giuseppe Nisticó; Gino Doria

doi:10.1016/0162-3109(92)90031-7

Melatonin as immunompdulator in immunodeficient mice

M. Cristina Caroleo, Daniela Frasca, Giuseppe Nisticó, Gino Doria

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

Melatonin, the main hormone of the pineal gland, when chronically injected into young mice or mice immuno-depressed by aging or by cyclophosphamide treatment, is able to enhance the antibody response to a T-dependent antigen. The enhancement of the antibody response is associated with increased induction of T helper cell activity and IL-2 production, as evidenced in mice immunodepressed by aging or by cyclophosphamide treatment. These observations suggest that melatonin treatment may be successfully used in the therapy of immunodepressive conditions.

Original language	English (US)
Pages (from-to)	81-89
Number of pages	9
Journal	Immunopharmacology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/0162-3109(92)90031-7
State	Published - Mar 4 1992
Externally published	Yes

Keywords

Antibody
IL-2
Immunodeficiency
Melatonin
T cell

ASJC Scopus subject areas

Pharmacology

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10.1016/0162-3109(92)90031-7

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title = "Melatonin as immunompdulator in immunodeficient mice",

abstract = "Melatonin, the main hormone of the pineal gland, when chronically injected into young mice or mice immuno-depressed by aging or by cyclophosphamide treatment, is able to enhance the antibody response to a T-dependent antigen. The enhancement of the antibody response is associated with increased induction of T helper cell activity and IL-2 production, as evidenced in mice immunodepressed by aging or by cyclophosphamide treatment. These observations suggest that melatonin treatment may be successfully used in the therapy of immunodepressive conditions.",

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AU - Caroleo, M. Cristina

AU - Frasca, Daniela

AU - Nisticó, Giuseppe

AU - Doria, Gino

PY - 1992/3/4

Y1 - 1992/3/4

N2 - Melatonin, the main hormone of the pineal gland, when chronically injected into young mice or mice immuno-depressed by aging or by cyclophosphamide treatment, is able to enhance the antibody response to a T-dependent antigen. The enhancement of the antibody response is associated with increased induction of T helper cell activity and IL-2 production, as evidenced in mice immunodepressed by aging or by cyclophosphamide treatment. These observations suggest that melatonin treatment may be successfully used in the therapy of immunodepressive conditions.

AB - Melatonin, the main hormone of the pineal gland, when chronically injected into young mice or mice immuno-depressed by aging or by cyclophosphamide treatment, is able to enhance the antibody response to a T-dependent antigen. The enhancement of the antibody response is associated with increased induction of T helper cell activity and IL-2 production, as evidenced in mice immunodepressed by aging or by cyclophosphamide treatment. These observations suggest that melatonin treatment may be successfully used in the therapy of immunodepressive conditions.

KW - Antibody

KW - IL-2

KW - Immunodeficiency

KW - Melatonin

KW - T cell

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Melatonin as immunompdulator in immunodeficient mice

Abstract

Keywords

ASJC Scopus subject areas

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