Melatonin as immunompdulator in immunodeficient mice

M. Cristina Caroleo, Daniela Frasca, Giuseppe Nisticó, Gino Doria

Research output: Contribution to journalArticlepeer-review

120 Scopus citations


Melatonin, the main hormone of the pineal gland, when chronically injected into young mice or mice immuno-depressed by aging or by cyclophosphamide treatment, is able to enhance the antibody response to a T-dependent antigen. The enhancement of the antibody response is associated with increased induction of T helper cell activity and IL-2 production, as evidenced in mice immunodepressed by aging or by cyclophosphamide treatment. These observations suggest that melatonin treatment may be successfully used in the therapy of immunodepressive conditions.

Original languageEnglish (US)
Pages (from-to)81-89
Number of pages9
Issue number2
StatePublished - Mar 4 1992
Externally publishedYes


  • Antibody
  • IL-2
  • Immunodeficiency
  • Melatonin
  • T cell

ASJC Scopus subject areas

  • Pharmacology


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