Melanoma's high C>T mutation rate: Is deamination playing a role?

Margaret I. Sanchez, James M. Grichnik

Research output: Contribution to journalComment/debate

3 Scopus citations

Abstract

The majority of melanoma mutations are C>T transitions, and most bear UV signatures. However, other process may contribute to the high C>T mutation rate. Okura et al., have demonstrated immunohistochemical evidence of deaminating enzymes, activation-induced cytidine deaminase (AID) and apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3B (APOBEC3B) in melanoma. Both have been implicated in cancer. While further validation is necessary, these findings warrant consideration of a role for deamination in melanomagenesis. Deamination primarily drives C>T transitions. Compared with trunk/extremity melanomas, acral melanomas display a significantly higher percentage of 'spontaneous' and 'AID' mutation signature events suggesting deamination may be particularly important in this subgroup.

Original languageEnglish (US)
Pages (from-to)551-552
Number of pages2
JournalExperimental dermatology
Volume23
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • BRAF
  • Deaminase
  • Melanoma
  • Mutagenesis

ASJC Scopus subject areas

  • Dermatology
  • Molecular Biology
  • Biochemistry

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