Melanocytes as "sensory" and regulatory cells in the epidermis

Andrzej Slominski, Ralf Paus, Dirk Schadendorf

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Epidermal melanocytes (MC) are pigment-producing and secretorily active cells of neural crest origin that communicate directly with multiple targets. Here, we propose that normal epidermal MC also are "sensory" and regulatory cells operating in the context of a regulatory network for the maintenance of human epidermal homeostasis. Altered regulatory MC functions may play a role in selected skin diseases, and racial pigmentation may affect cutaneous functions.

Original languageEnglish (US)
Pages (from-to)103-120
Number of pages18
JournalJournal of Theoretical Biology
Volume164
Issue number1
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Epidermis
melanocytes
Melanocytes
epidermis (animal)
Homeostasis
Regulatory Networks
Cell
Pigments
Skin
Maintenance
neural crest
Neural Crest
Pigmentation
skin diseases
cells
Skin Diseases
pigmentation
Target
homeostasis
pigments

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Melanocytes as "sensory" and regulatory cells in the epidermis. / Slominski, Andrzej; Paus, Ralf; Schadendorf, Dirk.

In: Journal of Theoretical Biology, Vol. 164, No. 1, 01.01.1993, p. 103-120.

Research output: Contribution to journalArticle

Slominski, Andrzej ; Paus, Ralf ; Schadendorf, Dirk. / Melanocytes as "sensory" and regulatory cells in the epidermis. In: Journal of Theoretical Biology. 1993 ; Vol. 164, No. 1. pp. 103-120.
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