Melanocytes as "sensory" and regulatory cells in the epidermis

Andrzej Slominski, Ralf Paus, Dirk Schadendorf

Research output: Contribution to journalArticlepeer-review

133 Scopus citations


Epidermal melanocytes (MC) are pigment-producing and secretorily active cells of neural crest origin that communicate directly with multiple targets. Here, we propose that normal epidermal MC also are "sensory" and regulatory cells operating in the context of a regulatory network for the maintenance of human epidermal homeostasis. Altered regulatory MC functions may play a role in selected skin diseases, and racial pigmentation may affect cutaneous functions.

Original languageEnglish (US)
Pages (from-to)103-120
Number of pages18
JournalJournal of theoretical biology
Issue number1
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics


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