Mediterranean diet and white matter hyperintensity volume in the Northern Manhattan study

Hannah Gardener, Nikolaos Scarmeas, Yian Gu, Bernadette Boden-Albala, Mitchell S V Elkind, Ralph L Sacco, Charles DeCarli, Clinton B Wright

Research output: Contribution to journalArticle

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Abstract

Objective: To examine the association between a Mediterranean-style diet (MeDi) and brain magnetic resonance imaging white matter hyperintensity volume (WMHV). Design: A cross-sectional analysis within a longitudinal population-based cohort study. A semiquantitative food frequency questionnaire was administered, and a score (range, 0-9) was calculated to reflect increasing similarity to the MeDi pattern. Setting: The Northern Manhattan Study. Participants: A total of 1091 participants, of whom 966 had dietary information (mean age, 72 years; 59.3% women, 64.6% Hispanic, 15.6% white, and 17.5% black). Main Outcome Measures: The WMHV was measured by quantitative brain magnetic resonance imaging. Linear regression models were constructed to examine the association between the MeDi score and the log-transformed WMHV as a proportion of total cranial volume, controlling for sociodemographic and vascular risk factors. Results: On the MeDi scale, 11.6% scored 0 to 2, 15.8% scored 3, 23.0% scored 4, 23.5% scored 5, and 26.1% scored 6 to 9. Each 1-point increase in MeDi score was associated with a lower log WMHV (β=-.04, P=.01). The only MeDi score component that was an independent predictor of WMHV was the ratio of monounsaturated to saturated fat (β=-.20, P=.001). Conclusions: A MeDi was associated with a lower WMHV burden, a marker of small vessel damage in the brain. However, white matter hyperintensities are etiologically heterogenous and can include neurodegeneration. Replication by other population-based studies is needed.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalArchives of Neurology
Volume69
Issue number2
DOIs
StatePublished - Feb 1 2012

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Mediterranean Diet
Linear Models
Brain
Magnetic Resonance Imaging
White Matter
Manhattan
Diet
Hispanic Americans
Population
Cohort Studies
Cross-Sectional Studies
Fats
Outcome Assessment (Health Care)
Food

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Gardener, H., Scarmeas, N., Gu, Y., Boden-Albala, B., Elkind, M. S. V., Sacco, R. L., ... Wright, C. B. (2012). Mediterranean diet and white matter hyperintensity volume in the Northern Manhattan study. Archives of Neurology, 69(2), 251-256. https://doi.org/10.1001/archneurol.2011.548

Mediterranean diet and white matter hyperintensity volume in the Northern Manhattan study. / Gardener, Hannah; Scarmeas, Nikolaos; Gu, Yian; Boden-Albala, Bernadette; Elkind, Mitchell S V; Sacco, Ralph L; DeCarli, Charles; Wright, Clinton B.

In: Archives of Neurology, Vol. 69, No. 2, 01.02.2012, p. 251-256.

Research output: Contribution to journalArticle

Gardener, H, Scarmeas, N, Gu, Y, Boden-Albala, B, Elkind, MSV, Sacco, RL, DeCarli, C & Wright, CB 2012, 'Mediterranean diet and white matter hyperintensity volume in the Northern Manhattan study', Archives of Neurology, vol. 69, no. 2, pp. 251-256. https://doi.org/10.1001/archneurol.2011.548
Gardener, Hannah ; Scarmeas, Nikolaos ; Gu, Yian ; Boden-Albala, Bernadette ; Elkind, Mitchell S V ; Sacco, Ralph L ; DeCarli, Charles ; Wright, Clinton B. / Mediterranean diet and white matter hyperintensity volume in the Northern Manhattan study. In: Archives of Neurology. 2012 ; Vol. 69, No. 2. pp. 251-256.
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