Medical treatment and prevention of peptic ulcer disease

A. I. Rogers

Research output: Contribution to journalArticle

Abstract

Many agents seem to be equally effective for the treatment of peptic ulcer disease. This is true despite the drugs' varied mechanisms of action, and this observation has caused investigators to shift their focus from aggressive to defensive factors when studying ulcer pathogenesis. Patients with a healed ulcer are always at risk for recurrence, and guidelines are available for management of these patients. Ulcer prevention becomes a crucial issue in intensive care units where critically ill patients have many known risk factors. Maintaining a gastric pH above 4.0 appears to reduce the morbidity and mortality associated with such stress-induced ulcers. Use of nonsteroidal anti-inflammatory drugs increases ulcer risk and complications in the elderly, in women with rheumatoid arthritis, and in smokers and abusers of alcohol. Prophylaxis with the synthetic prostaglandin analogue misoprostol (Cytotec) appears to reduce this risk.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalPostgraduate Medicine
Volume88
Issue number5
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Peptic Ulcer
Ulcer
Synthetic Prostaglandins
Misoprostol
Therapeutics
Critical Illness
Pharmaceutical Preparations
Intensive Care Units
Rheumatoid Arthritis
Stomach
Anti-Inflammatory Agents
Alcohols
Research Personnel
Guidelines
Morbidity
Recurrence
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Medical treatment and prevention of peptic ulcer disease. / Rogers, A. I.

In: Postgraduate Medicine, Vol. 88, No. 5, 01.01.1990, p. 57-60.

Research output: Contribution to journalArticle

Rogers, A. I. / Medical treatment and prevention of peptic ulcer disease. In: Postgraduate Medicine. 1990 ; Vol. 88, No. 5. pp. 57-60.
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