Medical therapy for spermatogenic failure

Ranjith Ramasamy, Peter J. Stahl, Peter N. Schlegel

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Medical treatment of men with primary spermatogenic failure remains largely ineffective in contrast to those with secondary testicular failure. Treatment has been attempted with a multitude of agents ranging from hormones to nutritional supplements (antioxidants). While some studies have demonstrated benefit to some treatments, no treatments have consistently demonstrated efficacy nor has it been possible to reliably identify patients likely to benefit. Idiopathic spermatogenic failure likely results from multiple discrete defects in sperm production that are as yet unidentified. A better understanding of these defects will yield more effective treatment options and appropriate triage of patients to specific therapeutic regimens. This review focuses on the rationale and current evidence for hormonal and antioxidant therapy in medical treatment of male infertility, spermatogenic failure in particular. Although empiric medical therapy for spermatogenic failure has been largely replaced by assisted reproductive techniques, both treatment modalities could play a role, perhaps as combination therapy.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalAsian Journal of Andrology
Issue number1
StatePublished - Jan 2012
Externally publishedYes


  • antioxidant
  • hormones
  • male infertility
  • sperm
  • spermatogenesis
  • spermatogenic failure
  • testicular failure

ASJC Scopus subject areas

  • Urology


Dive into the research topics of 'Medical therapy for spermatogenic failure'. Together they form a unique fingerprint.

Cite this