Medical management of ankylosing spondylitis

Alexander A. Khalessi, Bryan C. Oh, Michael Y. Wang

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


In the fol1owing literature review the authors consider the available evidence for the medical management of patients with ankylosing spondylitis (AS), and they critically assess current treatment guidelines. Medical therapy for axial disease in AS emphasizes improvement in patients' pain and overall function. First-line treatments include individualized physical therapy and nonsteroidal antiinflammatory drugs (NSAIDs) in conjunction with gastroprotective therapy. After an adequate trial of therapy with two NSAIDs exceeding 3 months or limited by medication toxicity, the patient may undergo tumor necrosis factor-α blockade therapy. Response should occur within 6-12 weeks, and patients must undergo tuberculosis screening. Evidence does not currently support the use of disease modifying antirheumatic drugs, corticosteroids, or radiotherapy in AS.

Original languageEnglish (US)
Article numberE4
JournalNeurosurgical focus
Issue number1
StatePublished - Jan 2008


  • Ankylosing spondylitis
  • Medical management
  • Nonsteroidal antiinflammatory drug
  • Tumor necrosis factor-α blockade

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Medical management of ankylosing spondylitis'. Together they form a unique fingerprint.

Cite this