Medical history of chemotherapy or immunosuppressive drug treatment and risk of amyotrophic lateral sclerosis (ALS)

Thomas Kuczmarski, Elijah W. Stommel, Kristen Riley, Rup Tandan, Vinay Chaudhry, Lora Clawson, Tracie A. Caller, Patricia L. Henegan, Dominic N. Facciponte, Walter G Bradley, Angeline S. Andrew

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A recent population-based analysis demonstrated lower risk of the lethal degenerative neuromuscular disease, amyotrophic lateral sclerosis (ALS) associated with history of the use of ‘antineoplastic agents’ and ‘immunosuppressants’. To see if this finding was generalizable to other ALS cohorts, we examined associations between use of these agents and ALS risk in an independent case–control study of n = 414 ALS patients and n = 361 controls in an Eastern US population. Controls were sampled from the general population and among non-neurodegenerative disease patients. A history of chemotherapy treatment was significantly associated with a decreased ALS risk (OR 0.46, 95% CI 0.22–0.89, P = 0.026). We did not observe an association between risk of ALS and immunosuppressant therapy use (OR 0.78, 95% CI 0.50–1.02, P = 0.23). Analyses were adjusted for age, gender, and smoking. Our results support the prior report for chemotherapy treatment and lead to further discussion of the underlying mechanism.

Original languageEnglish (US)
Pages (from-to)1763-1767
Number of pages5
JournalJournal of Neurology
Volume264
Issue number8
DOIs
StatePublished - Aug 1 2017

Keywords

  • Amyotrophic lateral sclerosis
  • Case–control
  • Chemotherapy
  • Immunosuppressant
  • Neurodegenerative

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Kuczmarski, T., Stommel, E. W., Riley, K., Tandan, R., Chaudhry, V., Clawson, L., Caller, T. A., Henegan, P. L., Facciponte, D. N., Bradley, W. G., & Andrew, A. S. (2017). Medical history of chemotherapy or immunosuppressive drug treatment and risk of amyotrophic lateral sclerosis (ALS). Journal of Neurology, 264(8), 1763-1767. https://doi.org/10.1007/s00415-017-8564-2