Medical comorbidities in patients with lichen planopilaris, a retrospective case–control study

Raymond M. Fertig, Shasa Hu, Austin J. Maddy, Alexandra Balaban, Nouf Aleid, Adam Aldahan, Antonella Tosti

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Lichen planopilaris (LPP) is a rare inflammatory lymphocyte-mediated disease of the scalp considered to have an autoimmune pathogenesis. Objectives: To identify the prevalence of medical comorbidities in patients with classic LPP (CLPP) and frontal fibrosing alopecia (FFA). Methods: The medical records of 206 LPP patients and 323 control patients were retrospectively reviewed for existing comorbidities. The control group consisted of 257 patients with androgenetic alopecia (ICD 9 = 704.0 or ICD 10 = L64.9) and 66 patients with actinic keratosis (ICD 9 = 702.0 or ICD 10 = L57.0). Results: Systemic lupus erythematosus (SLE) was found in 4.37% of all patients with LPP (including CLPP and the FFA subtype) and in 0.31% of controls. Female patients with the FFA subtype were more likely to have SLE than controls (OR 31.034, 95% CI 2.405–400.382, P = 0.0085). Limitations: This study is limited in that it is a retrospective chart review. Conclusion: Female patients with FFA are significantly more likely to have SLE. Patients with LPP (including CLPP and the FFA subtype) are less likely to have diabetes. Patients with CLPP excluding FFA are less likely to have hypertension, heart disease, and hypothyroidism.

Original languageEnglish (US)
Pages (from-to)804-809
Number of pages6
JournalInternational Journal of Dermatology
Volume57
Issue number7
DOIs
StatePublished - Jul 1 2018

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Medical comorbidities in patients with lichen planopilaris, a retrospective case–control study'. Together they form a unique fingerprint.

Cite this