Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields

Jay Z. Parrish, Kazuo Emoto, Michael D. Kim, Nung Jan Yuh

Research output: Contribution to journalReview article

192 Scopus citations

Abstract

Although dendrite arborization patterns are hallmarks of neuronal type and critical determinants of neuronal function, how dendritic arbors take shape is still largely unknown. Transcription factors play important roles in specifying neuronal types and have a profound influence on dendritic arbor size and complexity. The space that a dendritic arbor occupies is determined largely by a combination of growth-promoting signals that regulate arbor size, chemotropic cues that steer dendrites into the appropriate space, and neurite-neurite contacts that ensure proper representation of the dendritic field and appropriate synaptic contacts. Dendritic arbors are largely maintained over the neuron's lifetime, but in some cases, dendritic arbors are refined, in large part as a result of neuronal activity. In this review, we summarize our current understanding of the cellular and molecular mechanisms that regulate dendritic field formation and influence the shaping of dendritic arbors.

Original languageEnglish (US)
Pages (from-to)399-423
Number of pages25
JournalAnnual Review of Neuroscience
Volume30
DOIs
StatePublished - Aug 13 2007

Keywords

  • Dendrite
  • Neuron
  • Plasticity
  • Routing
  • Synapse
  • Tiling
  • Wiring

ASJC Scopus subject areas

  • Neuroscience(all)

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