Mechanisms of vertebrate germ cell determination

Tristan Aguero, Susannah Kassmer, Ramiro Alberio, Andrew Johnson, Mary Lou L King

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

Two unique characteristics of the germ line are the ability to persist from generation to generation and to retain full developmental potential while differentiating into gametes. How the germ line is specified that allows it to retain these characteristics within the context of a developing embryo remains unknown and is one focus of current research. Germ cell specification proceeds through one of two basic mechanisms: cell autonomous or inductive. Here, we discuss how germ plasm driven germ cell specification (cell autonomous) occurs in both zebrafish and the frog Xenopus. We describe the segregation of germ cells during embryonic development of solitary and colonial ascidians to provide an evolutionary context to both mechanisms. We conclude with a discussion of the inductive mechanism as exemplified by both the mouse and axolotl model systems. Regardless of mechanism, several general themes can be recognized including the essential role of repression and posttranscriptional regulation of gene expression.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages383-440
Number of pages58
Volume953
DOIs
StatePublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume953
ISSN (Print)00652598
ISSN (Electronic)22148019

Fingerprint

Germ Cells
Vertebrates
Cells
Specifications
Gene expression
Ambystoma mexicanum
Urochordata
Gene Expression Regulation
Zebrafish
Xenopus
Anura
Embryonic Development
Embryonic Structures
Research

Keywords

  • Ascidians
  • Axolotl
  • Cell-autonomous
  • Gene network or genetics
  • Germ line primordial germ cells
  • Inductive
  • Mouse
  • Xenopus
  • Zebrafish

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Aguero, T., Kassmer, S., Alberio, R., Johnson, A., & King, M. L. L. (2017). Mechanisms of vertebrate germ cell determination. In Advances in Experimental Medicine and Biology (Vol. 953, pp. 383-440). (Advances in Experimental Medicine and Biology; Vol. 953). Springer New York LLC. https://doi.org/10.1007/978-3-319-46095-6_8

Mechanisms of vertebrate germ cell determination. / Aguero, Tristan; Kassmer, Susannah; Alberio, Ramiro; Johnson, Andrew; King, Mary Lou L.

Advances in Experimental Medicine and Biology. Vol. 953 Springer New York LLC, 2017. p. 383-440 (Advances in Experimental Medicine and Biology; Vol. 953).

Research output: Chapter in Book/Report/Conference proceedingChapter

Aguero, T, Kassmer, S, Alberio, R, Johnson, A & King, MLL 2017, Mechanisms of vertebrate germ cell determination. in Advances in Experimental Medicine and Biology. vol. 953, Advances in Experimental Medicine and Biology, vol. 953, Springer New York LLC, pp. 383-440. https://doi.org/10.1007/978-3-319-46095-6_8
Aguero T, Kassmer S, Alberio R, Johnson A, King MLL. Mechanisms of vertebrate germ cell determination. In Advances in Experimental Medicine and Biology. Vol. 953. Springer New York LLC. 2017. p. 383-440. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-46095-6_8
Aguero, Tristan ; Kassmer, Susannah ; Alberio, Ramiro ; Johnson, Andrew ; King, Mary Lou L. / Mechanisms of vertebrate germ cell determination. Advances in Experimental Medicine and Biology. Vol. 953 Springer New York LLC, 2017. pp. 383-440 (Advances in Experimental Medicine and Biology).
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