Mechanisms of vascular injury: The emerging role of the endothelium

Leopoldo Raij

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Evidence is increasing that vascular tone is highly dependent on the health of the endothelium and on the delicate balancing act between endothelium-derived relaxing and endothelium-derived contracting factors. Moreover, there is also evidence supporting the notion that the same factors which affect vascular tone also regulate, either in an autocrine or paracrine fashion, changes in vascular architecture. Synthesis and release of both endothelium-derived relaxing and contracting factors are affected by a number of physiologic and therapeutic agents as well as by other factors, among them vascular injury in disease states such as atherosclerosis, hypertension, diabetes, and acute renal failure. A number of trials indicate that therapeutic intervention may be capable of modulating the synthesis and release of these substances and the balance between the two as well as influencing the processes which control vascular remodeling.

Original languageEnglish
JournalJournal of the American Society of Nephrology
Volume2
Issue number2 SUPPL.
StatePublished - Aug 1 1991
Externally publishedYes

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Vascular System Injuries
Endothelium
Blood Vessels
Endothelium-Dependent Relaxing Factors
Acute Kidney Injury
Atherosclerosis
Hypertension
Health
Therapeutics

Keywords

  • Acute renal failure
  • Atherosclerosis
  • Diabetes
  • Endothelium
  • Hypertension

ASJC Scopus subject areas

  • Nephrology

Cite this

Mechanisms of vascular injury : The emerging role of the endothelium. / Raij, Leopoldo.

In: Journal of the American Society of Nephrology, Vol. 2, No. 2 SUPPL., 01.08.1991.

Research output: Contribution to journalArticle

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