Mechanisms of the blood-brain barrier disruption in HIV-1 infection

Michal Toborek, Yong Woo Lee, Govinder Flora, Hong Pu, Ibolya E. András, Edward Wylegala, Bernhard Hennig, Avindra Nath

Research output: Contribution to journalReview article

162 Scopus citations

Abstract

1. Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). 2. It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. 3. The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.

Original languageEnglish (US)
Pages (from-to)181-199
Number of pages19
JournalCellular and molecular neurobiology
Volume25
Issue number1
DOIs
StatePublished - Feb 1 2005
Externally publishedYes

Keywords

  • AIDS
  • Blood-brain barrier
  • Brain endothelial cells
  • HIV
  • Inflammatory responses
  • Tat
  • Tight junction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Biochemistry
  • Cell Biology
  • Genetics

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