Mechanisms of pulmonary microvascular dysfunction during severe burn injury

Richard H. Turnage, Fiemu Nwariaku, Joseph Murphy, Carl I Schulman, Keith Wright, Helen Yin

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Even in the absence of inhalational injury, acute lung injury is a common cause of morbidity and mortality for patients sustaining severe burns. Other than general supportive measures, there are few therapeutic options for improving survival in these critically ill patients. Numerous clinical and laboratory studies have implicated tumor necrosis factor (TNF)-α and neutrophils as important participants in the pathogenesis of burn-induced lung injury. There is, however, little information regarding the mechanism by which these and other pro-inflammatory mediators affect the movement of fluid and protein across the microvascular barrier into the interstitium of the lung. In addition to reviewing the evidence implicating TNF-α and neutrophils in the pathophysiology of burn-induced lung injury, this report summarizes current theories regarding potential mechanisms by which these mediators may alter microvascular barrier function to lead ultimately to the development of pulmonary edema.

Original languageEnglish
Pages (from-to)848-853
Number of pages6
JournalWorld Journal of Surgery
Volume26
Issue number7
DOIs
StatePublished - Jul 1 2002
Externally publishedYes

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Burns
Lung Injury
Lung
Wounds and Injuries
Neutrophils
Tumor Necrosis Factor-alpha
Acute Lung Injury
Pulmonary Edema
Critical Illness
Morbidity
Survival
Mortality
Proteins
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Mechanisms of pulmonary microvascular dysfunction during severe burn injury. / Turnage, Richard H.; Nwariaku, Fiemu; Murphy, Joseph; Schulman, Carl I; Wright, Keith; Yin, Helen.

In: World Journal of Surgery, Vol. 26, No. 7, 01.07.2002, p. 848-853.

Research output: Contribution to journalArticle

Turnage, Richard H. ; Nwariaku, Fiemu ; Murphy, Joseph ; Schulman, Carl I ; Wright, Keith ; Yin, Helen. / Mechanisms of pulmonary microvascular dysfunction during severe burn injury. In: World Journal of Surgery. 2002 ; Vol. 26, No. 7. pp. 848-853.
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