Mechanisms of normal and malignant breast epithelial growth regulation

Marc E Lippman, Robert B. Dickson

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

In this presentation we review information highlighting the multiple roles of both steroidal and polypeptide regulators of mammary epithelial cell growth with some additional emphasis on the work of our laboratory. The effects of both classes of hormones are complex and involve multiple interactions with epithelial components (malignant or normal) and the stromal compartment. Estrogens induce growth regulatory polypeptide growth factors which are responsible for many of the induced phenotypic effects in hormone-dependent breast cancer. Progression of hormone-dependent breast cancer to hormone independence probably involves multiple genetic mechanisms of oncogene activation, loss of the estrogen receptor, or loss of hormone responsivity of other gene products. Initial carcinogenesis and progression of mammary epithelium to cancer probably also requires both proliferative stimuli (estrogen, polypeptide growth factors) and genetic damage, leading to qualitatively different hormonal responses (hormone responsive cancer). New therapeutic strategies based on these biological considerations are emerging, including a variety of approaches which interfere at multiple points with ability of ligand to induce receptor signaling.

Original languageEnglish
Pages (from-to)107-121
Number of pages15
JournalJournal of Steroid Biochemistry
Volume34
Issue number1-6
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Breast
Hormones
Growth
Peptides
Intercellular Signaling Peptides and Proteins
Estrogens
Breast Neoplasms
Cell growth
Oncogenes
Estrogen Receptors
Neoplasms
Carcinogenesis
Epithelium
Genes
Epithelial Cells
Chemical activation
Ligands
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Mechanisms of normal and malignant breast epithelial growth regulation. / Lippman, Marc E; Dickson, Robert B.

In: Journal of Steroid Biochemistry, Vol. 34, No. 1-6, 01.01.1989, p. 107-121.

Research output: Contribution to journalArticle

Lippman, Marc E ; Dickson, Robert B. / Mechanisms of normal and malignant breast epithelial growth regulation. In: Journal of Steroid Biochemistry. 1989 ; Vol. 34, No. 1-6. pp. 107-121.
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