Abstract
Different physiological adaptations for anoxia resistance have been described in the animal kingdom. These adaptations are particularly important in organs that are highly susceptible to energy deprivation such as the heart and brain. Among vertebrates, turtles are one of the species that are highly tolerant to anoxia. In mammals however, insults such as anoxia, ischemia and hypoglycemia, all cause major histopathological events to the brain. However, in mammals even ischemic or anoxic tolerance is found when a sublethal ischemic/anoxic insult is induced sometime before a lethal ischemic/anoxic insult is induced. This phenomenon is defined as ischemic preconditioning. Better understanding of the mechanisms inducing both anoxic tolerance in turtles or ischemic preconditioning in mammals may provide novel therapeutic interventions that may aide mammalian brain to resist the ravages of cerebral ischemia. In this review, we will summarize some of the mechanisms implemented in both models of tolerance, emphasizing physiological and biochemical similarities.
| Original language | English |
|---|---|
| Pages (from-to) | 291-299 |
| Number of pages | 9 |
| Journal | Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology |
| Volume | 147 |
| Issue number | 2 SPEC. ISS. |
| DOIs | |
| State | Published - Jun 1 2007 |
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Keywords
- Anoxia
- Ischemia
- Neuroprotective mechanism
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Physiology
Cite this
Mechanisms of neuroprotection during ischemic preconditioning : Lessons from anoxic tolerance. / Perez-Pinzon, Miguel.
In: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, Vol. 147, No. 2 SPEC. ISS., 01.06.2007, p. 291-299.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanisms of neuroprotection during ischemic preconditioning
T2 - Lessons from anoxic tolerance
AU - Perez-Pinzon, Miguel
PY - 2007/6/1
Y1 - 2007/6/1
N2 - Different physiological adaptations for anoxia resistance have been described in the animal kingdom. These adaptations are particularly important in organs that are highly susceptible to energy deprivation such as the heart and brain. Among vertebrates, turtles are one of the species that are highly tolerant to anoxia. In mammals however, insults such as anoxia, ischemia and hypoglycemia, all cause major histopathological events to the brain. However, in mammals even ischemic or anoxic tolerance is found when a sublethal ischemic/anoxic insult is induced sometime before a lethal ischemic/anoxic insult is induced. This phenomenon is defined as ischemic preconditioning. Better understanding of the mechanisms inducing both anoxic tolerance in turtles or ischemic preconditioning in mammals may provide novel therapeutic interventions that may aide mammalian brain to resist the ravages of cerebral ischemia. In this review, we will summarize some of the mechanisms implemented in both models of tolerance, emphasizing physiological and biochemical similarities.
AB - Different physiological adaptations for anoxia resistance have been described in the animal kingdom. These adaptations are particularly important in organs that are highly susceptible to energy deprivation such as the heart and brain. Among vertebrates, turtles are one of the species that are highly tolerant to anoxia. In mammals however, insults such as anoxia, ischemia and hypoglycemia, all cause major histopathological events to the brain. However, in mammals even ischemic or anoxic tolerance is found when a sublethal ischemic/anoxic insult is induced sometime before a lethal ischemic/anoxic insult is induced. This phenomenon is defined as ischemic preconditioning. Better understanding of the mechanisms inducing both anoxic tolerance in turtles or ischemic preconditioning in mammals may provide novel therapeutic interventions that may aide mammalian brain to resist the ravages of cerebral ischemia. In this review, we will summarize some of the mechanisms implemented in both models of tolerance, emphasizing physiological and biochemical similarities.
KW - Anoxia
KW - Ischemia
KW - Neuroprotective mechanism
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UR - http://www.scopus.com/inward/citedby.url?scp=34247227508&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2006.08.032
DO - 10.1016/j.cbpa.2006.08.032
M3 - Article
VL - 147
SP - 291
EP - 299
JO - Comparative Biochemistry & Physiology; A: Comparative Physiology
JF - Comparative Biochemistry & Physiology; A: Comparative Physiology
SN - 1095-6433
IS - 2 SPEC. ISS.
ER -