Abstract
The mitochondrial oxidative phosphorylation system is formed by multimeric enzymes. In the yeast Saccharomyces cerevisiae, the bc1 complex, cytochrome c oxidase and the F1FO ATP synthase contain subunits of dual genetic origin. It has been recently established that key subunits of these enzymes, translated on mitochondrial ribosomes, are the subjects of assembly-dependent translational regulation. This type of control of gene expression plays a pivotal role in optimizing the biogenesis of mitochondrial respiratory membranes by coordinating protein synthesis and complex assembly and by limiting the accumulation of potentially harmful assembly intermediates. Here, the author will discuss the mechanisms governing translational regulation in yeast mitochondria in the light of the most recent discoveries in the field.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 397-408 |
| Number of pages | 12 |
| Journal | IUBMB Life |
| Volume | 65 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2013 |
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Keywords
- ATP synthase
- cytochrome c oxidase
- mitochondria
- Saccharomyces cerevisiae
- translational regulation
- ubiquinol cytochrome c oxidoreductase
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Clinical Biochemistry
- Molecular Biology
- Genetics
Cite this
Mechanisms of mitochondrial translational regulation. / Fontanesi, Flavia.
In: IUBMB Life, Vol. 65, No. 5, 05.2013, p. 397-408.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanisms of mitochondrial translational regulation
AU - Fontanesi, Flavia
PY - 2013/5
Y1 - 2013/5
N2 - The mitochondrial oxidative phosphorylation system is formed by multimeric enzymes. In the yeast Saccharomyces cerevisiae, the bc1 complex, cytochrome c oxidase and the F1FO ATP synthase contain subunits of dual genetic origin. It has been recently established that key subunits of these enzymes, translated on mitochondrial ribosomes, are the subjects of assembly-dependent translational regulation. This type of control of gene expression plays a pivotal role in optimizing the biogenesis of mitochondrial respiratory membranes by coordinating protein synthesis and complex assembly and by limiting the accumulation of potentially harmful assembly intermediates. Here, the author will discuss the mechanisms governing translational regulation in yeast mitochondria in the light of the most recent discoveries in the field.
AB - The mitochondrial oxidative phosphorylation system is formed by multimeric enzymes. In the yeast Saccharomyces cerevisiae, the bc1 complex, cytochrome c oxidase and the F1FO ATP synthase contain subunits of dual genetic origin. It has been recently established that key subunits of these enzymes, translated on mitochondrial ribosomes, are the subjects of assembly-dependent translational regulation. This type of control of gene expression plays a pivotal role in optimizing the biogenesis of mitochondrial respiratory membranes by coordinating protein synthesis and complex assembly and by limiting the accumulation of potentially harmful assembly intermediates. Here, the author will discuss the mechanisms governing translational regulation in yeast mitochondria in the light of the most recent discoveries in the field.
KW - ATP synthase
KW - cytochrome c oxidase
KW - mitochondria
KW - Saccharomyces cerevisiae
KW - translational regulation
KW - ubiquinol cytochrome c oxidoreductase
UR - http://www.scopus.com/inward/record.url?scp=84876941987&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876941987&partnerID=8YFLogxK
U2 - 10.1002/iub.1156
DO - 10.1002/iub.1156
M3 - Article
C2 - 23554047
AN - SCOPUS:84876941987
VL - 65
SP - 397
EP - 408
JO - IUBMB Life
JF - IUBMB Life
SN - 1521-6543
IS - 5
ER -