Mechanisms of levamisole‐induced granulocytopenia in breast cancer patients

Charles L. Vogel, Michael A. Silverman, Peter W. Mansell, Alan M. Miller, John S. Thompson, John M. Herbick, Dennis E. Brunskill, Darlene C. Padgett, E. Churchill McKinney, Everett V. Sugarbaker

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Five of 39 (13%) women treated with adjuvant combination chemotherapy plus levamisole immunotherapy after mastectomy for Stage II or III breast cancer developed levamisole-induced granulocytopenia. This complication occurred in each of the women between six and ten weeks after the completion of six months of combination chemoimmunotherapy when they were taking levamisole alone. Although none of the patients had an HLA B-27 locus and leukoagglutinins could not be demonstrated, complement-dependent, IgM mediated, peripheral destruction of granulocytes was documented using a microgranulocytotoxicity assay. In addition, a factor(s) present in serum from patients developing levamisole-induced granulocytopenia caused suppression of bone marrow granulocyte progenitor cells (CFU-C). The possible relationships between levamisole-induced peripheral granulocyte destruction and bone marrow CFU-C suppression are discussed.

Original languageEnglish (US)
Pages (from-to)171-183
Number of pages13
JournalAmerican Journal of Hematology
Volume9
Issue number2
DOIs
StatePublished - Sep 1980

Keywords

  • breast cancer
  • chemoimmunotherapy
  • levamisole granulocytopenia

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Mechanisms of levamisole‐induced granulocytopenia in breast cancer patients'. Together they form a unique fingerprint.

  • Cite this

    Vogel, C. L., Silverman, M. A., Mansell, P. W., Miller, A. M., Thompson, J. S., Herbick, J. M., Brunskill, D. E., Padgett, D. C., McKinney, E. C., & Sugarbaker, E. V. (1980). Mechanisms of levamisole‐induced granulocytopenia in breast cancer patients. American Journal of Hematology, 9(2), 171-183. https://doi.org/10.1002/ajh.2830090205