Mechanisms of Jak/STAT signaling in immunity and disease

Alejandro V. Villarino, Yuka Kanno, John R. Ferdinand, John J. O'Shea

Research output: Contribution to journalReview articlepeer-review

263 Scopus citations


More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the discovery of JAKs and their downstream effectors, the STAT proteins. This pathway has since become a paradigm for membraneto- nucleus signaling and explains how a broad range of soluble factors, including cytokines and hormones, mediate their diverse functions. Jak/STAT research has not only impacted basic science, particularly in the context of intercellular communication and cell-extrinsic control of gene expression, it also has become a prototype for transition from bench to bedside, culminating in the development and clinical implementation of pathway-specific therapeutics. This brief review synthesizes our current understanding of Jak/STAT biology while taking stock of the lessons learned and the challenges that lie ahead.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalJournal of Immunology
Issue number1
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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