Mechanisms of epigenetic memory and addiction

Luis M. Tuesta, Yi Zhang

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Epigenetic regulation of cellular identity and function is at least partly achieved through changes in covalent modifications on DNA and histones. Much progress has been made in recent years to understand how these covalent modifications affect cell identity and function. Despite the advances, whether and how epigenetic factors contribute to memory formation is still poorly understood. In this review, we discuss recent progress in elucidating epigenetic mechanisms of learning and memory, primarily at the DNA level, and look ahead to discuss their potential implications in reward memory and development of drug addiction. As part of our review series on Molecular Memory, Luis Tuesta and Yi Zhang discuss how epigenetic modifications, primarily at the DNA level, can impact memory formation and the development of drug addiction.

Original languageEnglish (US)
Pages (from-to)1091-1103
Number of pages13
JournalEMBO Journal
Issue number10
StatePublished - May 16 2014
Externally publishedYes


  • Addiction
  • DNA methylation
  • Epigenetics
  • Histone modifications
  • Learning & memory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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