Abstract
The present study evaluated the effect of in vivo administration of hydrocortisone (OHC) to normal subjects on the kinetics and function of naturally occurring and mitogen-induced suppressor cells (SC). It was demonstrated that in vivo OHC abrogates the function of naturally occurring SC and converts normal nonresponder peripheral blood (PB) cells to responder status. However, 4 hr following OHC administration at the point of maximal lymphocytopenia, the cells remaining in the circulation could still be activated by Con A to suppress. In addition, unstimulated cells obtained 4 hr after OHC administration markedly enhanced PFC responses when cocultured with fresh autologous cells. It was demonstrated that this enhanced PFC response was independent of 48-hr incubation, monocyte depletion, or changes in B-cell numbers and most likely represented a manifestation of in vivo OHC-induced changes in the circulatory kinetics of immunoregulatory cell populations.
| Original language | English |
|---|---|
| Pages (from-to) | 169-178 |
| Number of pages | 10 |
| Journal | Cellular Immunology |
| Volume | 44 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
- Immunology
Cite this
Mechanisms of corticosteroid action on lymphocyte subpopulations. V. Effects of in Vivo hydrocortisone on the circulatory kinetics and function of naturally occurring and mitogen-induced suppressor cells in man. / Haynes, Barton F.; Katz, Paul; Fauci, Anthony S.
In: Cellular Immunology, Vol. 44, No. 1, 01.01.1979, p. 169-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanisms of corticosteroid action on lymphocyte subpopulations. V. Effects of in Vivo hydrocortisone on the circulatory kinetics and function of naturally occurring and mitogen-induced suppressor cells in man
AU - Haynes, Barton F.
AU - Katz, Paul
AU - Fauci, Anthony S.
PY - 1979/1/1
Y1 - 1979/1/1
N2 - The present study evaluated the effect of in vivo administration of hydrocortisone (OHC) to normal subjects on the kinetics and function of naturally occurring and mitogen-induced suppressor cells (SC). It was demonstrated that in vivo OHC abrogates the function of naturally occurring SC and converts normal nonresponder peripheral blood (PB) cells to responder status. However, 4 hr following OHC administration at the point of maximal lymphocytopenia, the cells remaining in the circulation could still be activated by Con A to suppress. In addition, unstimulated cells obtained 4 hr after OHC administration markedly enhanced PFC responses when cocultured with fresh autologous cells. It was demonstrated that this enhanced PFC response was independent of 48-hr incubation, monocyte depletion, or changes in B-cell numbers and most likely represented a manifestation of in vivo OHC-induced changes in the circulatory kinetics of immunoregulatory cell populations.
AB - The present study evaluated the effect of in vivo administration of hydrocortisone (OHC) to normal subjects on the kinetics and function of naturally occurring and mitogen-induced suppressor cells (SC). It was demonstrated that in vivo OHC abrogates the function of naturally occurring SC and converts normal nonresponder peripheral blood (PB) cells to responder status. However, 4 hr following OHC administration at the point of maximal lymphocytopenia, the cells remaining in the circulation could still be activated by Con A to suppress. In addition, unstimulated cells obtained 4 hr after OHC administration markedly enhanced PFC responses when cocultured with fresh autologous cells. It was demonstrated that this enhanced PFC response was independent of 48-hr incubation, monocyte depletion, or changes in B-cell numbers and most likely represented a manifestation of in vivo OHC-induced changes in the circulatory kinetics of immunoregulatory cell populations.
UR - http://www.scopus.com/inward/record.url?scp=0018757375&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018757375&partnerID=8YFLogxK
U2 - 10.1016/0008-8749(79)90037-6
DO - 10.1016/0008-8749(79)90037-6
M3 - Article
C2 - 378416
AN - SCOPUS:0018757375
VL - 44
SP - 169
EP - 178
JO - Cellular Immunology
JF - Cellular Immunology
SN - 0008-8749
IS - 1
ER -