Mechanisms of cell death in the injured auditory system: Otoprotective strategies

Philippe P. Lefebvre, Brigitte Malgrange, François Lallemend, Hinrich Staecker, Gustave Moonen, Thomas R Van De Water

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Oxidative stress insults such as neurotrophin withdrawal, sound trauma, hypoxia/ischemia, ototoxic antibiotics, and chemotherapeutic agents have been shown to induce apoptosis of both auditory hair cells and neurons. In this paper, we review some components of the apoptotic pathways leading to the death of hair cells and auditory induced by growth factor withdrawal or cisplatin intoxication: (1) reactive oxygen species and free radicals are formed as by-products of several metabolic pathways and these molecules can themselves cause cell damage by reacting with cellular proteins; (2) activation of caspases, and (3) activation of calpain. These mechanisms have several different points at which inhibitors could be targeted to protect cells from programmed cell death, including the prevention of oxidative stress-induced apoptosis and the activation of caspases and calpains.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalAudiology and Neuro-Otology
Volume7
Issue number3
DOIs
StatePublished - Jun 22 2002

Fingerprint

Auditory Hair Cells
Calpain
Reactive Oxygen Species
Oxidative Stress
Cell Death
Apoptosis
Nerve Growth Factors
Caspases
Metabolic Networks and Pathways
Caspase 3
Cisplatin
Free Radicals
Intercellular Signaling Peptides and Proteins
Ischemia
Anti-Bacterial Agents
Neurons
Wounds and Injuries
Proteins

Keywords

  • Apoptosis
  • Auditory system
  • Calpain
  • Caspase
  • Cisplatin
  • Reactive oxygen species
  • Trophic factor withdrawal

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Neuroscience(all)
  • Physiology

Cite this

Lefebvre, P. P., Malgrange, B., Lallemend, F., Staecker, H., Moonen, G., & Van De Water, T. R. (2002). Mechanisms of cell death in the injured auditory system: Otoprotective strategies. Audiology and Neuro-Otology, 7(3), 165-170. https://doi.org/10.1159/000058304

Mechanisms of cell death in the injured auditory system : Otoprotective strategies. / Lefebvre, Philippe P.; Malgrange, Brigitte; Lallemend, François; Staecker, Hinrich; Moonen, Gustave; Van De Water, Thomas R.

In: Audiology and Neuro-Otology, Vol. 7, No. 3, 22.06.2002, p. 165-170.

Research output: Contribution to journalArticle

Lefebvre, PP, Malgrange, B, Lallemend, F, Staecker, H, Moonen, G & Van De Water, TR 2002, 'Mechanisms of cell death in the injured auditory system: Otoprotective strategies', Audiology and Neuro-Otology, vol. 7, no. 3, pp. 165-170. https://doi.org/10.1159/000058304
Lefebvre PP, Malgrange B, Lallemend F, Staecker H, Moonen G, Van De Water TR. Mechanisms of cell death in the injured auditory system: Otoprotective strategies. Audiology and Neuro-Otology. 2002 Jun 22;7(3):165-170. https://doi.org/10.1159/000058304
Lefebvre, Philippe P. ; Malgrange, Brigitte ; Lallemend, François ; Staecker, Hinrich ; Moonen, Gustave ; Van De Water, Thomas R. / Mechanisms of cell death in the injured auditory system : Otoprotective strategies. In: Audiology and Neuro-Otology. 2002 ; Vol. 7, No. 3. pp. 165-170.
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