Mechanisms for decreased function of B cells in aged mice and humans

Research output: Contribution to journalArticle

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Abstract

The immune system has been known for some time to be compromised in aged individuals, e.g., both mice and humans, and in both humoral and cellular responses. Our studies have begun to elucidate intrinsic B lymphocyte defects in Ig class switch recombination, activation-induced cytidine deaminase, and E47 transcription factor expression. These defects occur in both mice and humans. Our studies have also shown that tristetraprolin is one of the key players in regulating the decreased E47 mRNA stability in aged B lymphocytes. These and current studies should lead to improvements in B lymphocyte function in aged populations.

Original languageEnglish
Pages (from-to)2741-2746
Number of pages6
JournalJournal of Immunology
Volume180
Issue number5
StatePublished - Mar 1 2008

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B-Lymphocytes
Tristetraprolin
RNA Stability
Genetic Recombination
Immune System
Transcription Factors
Population
AICDA (activation-induced cytidine deaminase)

ASJC Scopus subject areas

  • Immunology

Cite this

Mechanisms for decreased function of B cells in aged mice and humans. / Frasca, Daniela; Landin, Ana Marie; Riley, Richard L; Blomberg, Bonnie B.

In: Journal of Immunology, Vol. 180, No. 5, 01.03.2008, p. 2741-2746.

Research output: Contribution to journalArticle

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