Mechanisms for decreased function of B cells in aged mice and humans

Research output: Contribution to journalShort surveypeer-review

75 Scopus citations


The immune system has been known for some time to be compromised in aged individuals, e.g., both mice and humans, and in both humoral and cellular responses. Our studies have begun to elucidate intrinsic B lymphocyte defects in Ig class switch recombination, activation-induced cytidine deaminase, and E47 transcription factor expression. These defects occur in both mice and humans. Our studies have also shown that tristetraprolin is one of the key players in regulating the decreased E47 mRNA stability in aged B lymphocytes. These and current studies should lead to improvements in B lymphocyte function in aged populations.

Original languageEnglish (US)
Pages (from-to)2741-2746
Number of pages6
JournalJournal of Immunology
Issue number5
StatePublished - Mar 1 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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