Mechanisms and consequences of Jak-STAT signaling in the immune system

Alejandro V. Villarino, Yuka Kanno, John J. O'Shea

Research output: Contribution to journalReview articlepeer-review

442 Scopus citations

Abstract

Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT ('signal transducer and activator of transcription') family constitute a rapid membrane-to-nucleus signaling module that affects every aspect of the mammalian immune system. Research on this paradigmatic pathway has experienced breakneck growth in the quarter century since its discovery and has yielded a stream of basic and clinical insights that have profoundly influenced modern understanding of human health and disease, exemplified by the bench-to-bedside success of Jak inhibitors ('jakinibs') and pathway-targeting drugs. Here we review recent advances in Jak-STAT biology, focusing on immune cell function, disease etiology and therapeutic intervention, as well as broader principles of gene regulation and signal-dependent TFs.

Original languageEnglish (US)
Pages (from-to)374-384
Number of pages11
JournalNature Immunology
Volume18
Issue number4
DOIs
StatePublished - Mar 22 2017
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'Mechanisms and consequences of Jak-STAT signaling in the immune system'. Together they form a unique fingerprint.

Cite this