Mechanism of neuronal migration

Wendou Yu, Jinzhu Zhang, Jiin Ju Chang

Research output: Contribution to journalArticle

Abstract

During development of central nervous system (CNS) of vertebrate, immature neurons migrate from the place of their proliferative zone to the final destination to exert their function. The neuronal migration with precise temporal and spatial pattern has been viewed as a discrete step in CNS development. Recent studies have shown that this process involves cooperation of a series of molecular events, including interactions of cell adhesive molecules, activation of ion channels, and organization of cytoskeloton. Therefore, it is important not only in elucidating the mechanism of neuronal migration, but also in gaining a new insight into the pathogenesis of brain disorders caused by defective neuronal migration to understand these events.

Original languageEnglish (US)
Pages (from-to)499-504
Number of pages6
JournalProgress in Biochemistry and Biophysics
Volume24
Issue number6
StatePublished - 1997
Externally publishedYes

Fingerprint

Neurology
Central Nervous System
Brain Diseases
Ion Channels
Cell Communication
Adhesives
Neurons
Vertebrates
Brain
Chemical activation
Molecules

Keywords

  • Calcium
  • Cell adhesive molecular
  • Cytoskeleton
  • Extracellular matrix protein
  • Glia cell
  • Migration
  • Neuron

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

Yu, W., Zhang, J., & Chang, J. J. (1997). Mechanism of neuronal migration. Progress in Biochemistry and Biophysics, 24(6), 499-504.

Mechanism of neuronal migration. / Yu, Wendou; Zhang, Jinzhu; Chang, Jiin Ju.

In: Progress in Biochemistry and Biophysics, Vol. 24, No. 6, 1997, p. 499-504.

Research output: Contribution to journalArticle

Yu, W, Zhang, J & Chang, JJ 1997, 'Mechanism of neuronal migration', Progress in Biochemistry and Biophysics, vol. 24, no. 6, pp. 499-504.
Yu, Wendou ; Zhang, Jinzhu ; Chang, Jiin Ju. / Mechanism of neuronal migration. In: Progress in Biochemistry and Biophysics. 1997 ; Vol. 24, No. 6. pp. 499-504.
@article{936479a8dfda490e875cf6a80e8cd8e2,
title = "Mechanism of neuronal migration",
abstract = "During development of central nervous system (CNS) of vertebrate, immature neurons migrate from the place of their proliferative zone to the final destination to exert their function. The neuronal migration with precise temporal and spatial pattern has been viewed as a discrete step in CNS development. Recent studies have shown that this process involves cooperation of a series of molecular events, including interactions of cell adhesive molecules, activation of ion channels, and organization of cytoskeloton. Therefore, it is important not only in elucidating the mechanism of neuronal migration, but also in gaining a new insight into the pathogenesis of brain disorders caused by defective neuronal migration to understand these events.",
keywords = "Calcium, Cell adhesive molecular, Cytoskeleton, Extracellular matrix protein, Glia cell, Migration, Neuron",
author = "Wendou Yu and Jinzhu Zhang and Chang, {Jiin Ju}",
year = "1997",
language = "English (US)",
volume = "24",
pages = "499--504",
journal = "Progress in Biochemistry and Biophysics",
issn = "1000-3282",
publisher = "Science Press",
number = "6",

}

TY - JOUR

T1 - Mechanism of neuronal migration

AU - Yu, Wendou

AU - Zhang, Jinzhu

AU - Chang, Jiin Ju

PY - 1997

Y1 - 1997

N2 - During development of central nervous system (CNS) of vertebrate, immature neurons migrate from the place of their proliferative zone to the final destination to exert their function. The neuronal migration with precise temporal and spatial pattern has been viewed as a discrete step in CNS development. Recent studies have shown that this process involves cooperation of a series of molecular events, including interactions of cell adhesive molecules, activation of ion channels, and organization of cytoskeloton. Therefore, it is important not only in elucidating the mechanism of neuronal migration, but also in gaining a new insight into the pathogenesis of brain disorders caused by defective neuronal migration to understand these events.

AB - During development of central nervous system (CNS) of vertebrate, immature neurons migrate from the place of their proliferative zone to the final destination to exert their function. The neuronal migration with precise temporal and spatial pattern has been viewed as a discrete step in CNS development. Recent studies have shown that this process involves cooperation of a series of molecular events, including interactions of cell adhesive molecules, activation of ion channels, and organization of cytoskeloton. Therefore, it is important not only in elucidating the mechanism of neuronal migration, but also in gaining a new insight into the pathogenesis of brain disorders caused by defective neuronal migration to understand these events.

KW - Calcium

KW - Cell adhesive molecular

KW - Cytoskeleton

KW - Extracellular matrix protein

KW - Glia cell

KW - Migration

KW - Neuron

UR - http://www.scopus.com/inward/record.url?scp=23744456450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744456450&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:23744456450

VL - 24

SP - 499

EP - 504

JO - Progress in Biochemistry and Biophysics

JF - Progress in Biochemistry and Biophysics

SN - 1000-3282

IS - 6

ER -