Perorala antidiabetikas verkningsmekanism: Sulfonylureapreparat stänger ATP-reglerad kaliumkanal

Translated title of the contribution: Mechanism of action of oral antidiabetics; Sulphonylureas block ATP-dependent potassium channels

Olof Larsson, Henrik Kindmark, Robert Bränström, Per Olof Berggren

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Although hypoglycaemic sulphonylureas have been used to treat non-insulin-dependent diabetes mellitus (NIDDM) for the past forty years, their mechanisms of action at the molecular level have only recently been elucidated. A combination of electrophysiological and molecular biological techniques showed the target of sulphonylureas to be a sulphonylurea receptor (SUR1) and potassium channel (Kir6.2) complex. Together, these two proteins form the ATP-dependent potassium (KATP) channel occurring in insulin- secreting cells. An increase in the blood glucose level triggers a chain of events in insulin-secreting cells and KATP channel closure which is a prerequisite for insulin secretion. In NIDDM, however, an increase in blood glucose fails to close the KATP channel satisfactorily, but this can be remedied by the administration of sulphonylureas.

Translated title of the contributionMechanism of action of oral antidiabetics; Sulphonylureas block ATP-dependent potassium channels
Original languageSwedish
Pages (from-to)4473-4477
Number of pages5
JournalLakartidningen
Issue number48
StatePublished - Nov 26 1997

ASJC Scopus subject areas

  • Medicine(all)

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    Larsson, O., Kindmark, H., Bränström, R., & Berggren, P. O. (1997). Perorala antidiabetikas verkningsmekanism: Sulfonylureapreparat stänger ATP-reglerad kaliumkanal. Lakartidningen, (48), 4473-4477.