Abstract
Objective: Since cerebral vasospasm (CV) was first described nearly half a century ago, significant progress has been made in understanding its underlying pathophysiology and developing treatment modalities. The purpose of this review is to discuss the rationale behind mechanical interventions for CV as well as the efficacy and complications associated with these treatment options. Methods: The authors summarize the pertinent literature on the mechanical treatment of CV, focusing first on balloon angioplasty, second on therapy combined with intra-arterial drug infusion, and concluding by briefly discussing intra-aortic balloon counterpulsation. The epidemiology, pathophysiology, technique, outcome, timing and complications are discussed for each treatment option. Results: A review of the relevant medical literature reveals that in the last 20 years, endovascular techniques including transluminal balloon angioplasty, intra-arterial drug infusion and newer experimental strategies have provided an important supplement to the established medical therapy. Discussion: Despite these developments, however, CV remains a major contributor to poor outcome following aSAH and continued efforts are necessary to improve and refine endovascular strategies as well as develop new treatment modalities.
| Original language | English |
|---|---|
| Pages (from-to) | 638-643 |
| Number of pages | 6 |
| Journal | Neurological Research |
| Volume | 31 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jul 1 2009 |
| Externally published | Yes |
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Keywords
- Angioplasty
- Endovascular treatment
- Subarachnoid hemorrhage
- Vasospasm
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Mechanical treatment of vasospasm. / Haque, Raqeeb; Kellner, Christopher P.; Komotar, Ricardo J; Connolly, E. Sander; Lavine, Sean D.; Solomon, Robert A.; Meyers, Philip M.
In: Neurological Research, Vol. 31, No. 6, 01.07.2009, p. 638-643.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanical treatment of vasospasm
AU - Haque, Raqeeb
AU - Kellner, Christopher P.
AU - Komotar, Ricardo J
AU - Connolly, E. Sander
AU - Lavine, Sean D.
AU - Solomon, Robert A.
AU - Meyers, Philip M.
PY - 2009/7/1
Y1 - 2009/7/1
N2 - Objective: Since cerebral vasospasm (CV) was first described nearly half a century ago, significant progress has been made in understanding its underlying pathophysiology and developing treatment modalities. The purpose of this review is to discuss the rationale behind mechanical interventions for CV as well as the efficacy and complications associated with these treatment options. Methods: The authors summarize the pertinent literature on the mechanical treatment of CV, focusing first on balloon angioplasty, second on therapy combined with intra-arterial drug infusion, and concluding by briefly discussing intra-aortic balloon counterpulsation. The epidemiology, pathophysiology, technique, outcome, timing and complications are discussed for each treatment option. Results: A review of the relevant medical literature reveals that in the last 20 years, endovascular techniques including transluminal balloon angioplasty, intra-arterial drug infusion and newer experimental strategies have provided an important supplement to the established medical therapy. Discussion: Despite these developments, however, CV remains a major contributor to poor outcome following aSAH and continued efforts are necessary to improve and refine endovascular strategies as well as develop new treatment modalities.
AB - Objective: Since cerebral vasospasm (CV) was first described nearly half a century ago, significant progress has been made in understanding its underlying pathophysiology and developing treatment modalities. The purpose of this review is to discuss the rationale behind mechanical interventions for CV as well as the efficacy and complications associated with these treatment options. Methods: The authors summarize the pertinent literature on the mechanical treatment of CV, focusing first on balloon angioplasty, second on therapy combined with intra-arterial drug infusion, and concluding by briefly discussing intra-aortic balloon counterpulsation. The epidemiology, pathophysiology, technique, outcome, timing and complications are discussed for each treatment option. Results: A review of the relevant medical literature reveals that in the last 20 years, endovascular techniques including transluminal balloon angioplasty, intra-arterial drug infusion and newer experimental strategies have provided an important supplement to the established medical therapy. Discussion: Despite these developments, however, CV remains a major contributor to poor outcome following aSAH and continued efforts are necessary to improve and refine endovascular strategies as well as develop new treatment modalities.
KW - Angioplasty
KW - Endovascular treatment
KW - Subarachnoid hemorrhage
KW - Vasospasm
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U2 - 10.1179/174313209X455745
DO - 10.1179/174313209X455745
M3 - Article
VL - 31
SP - 638
EP - 643
JO - Neurological Research
JF - Neurological Research
SN - 0161-6412
IS - 6
ER -