Mechanical treatment of vasospasm

Raqeeb Haque, Christopher P. Kellner, Ricardo J. Komotar, E. Sander Connolly, Sean D. Lavine, Robert A. Solomon, Philip M. Meyers

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Objective: Since cerebral vasospasm (CV) was first described nearly half a century ago, significant progress has been made in understanding its underlying pathophysiology and developing treatment modalities. The purpose of this review is to discuss the rationale behind mechanical interventions for CV as well as the efficacy and complications associated with these treatment options. Methods: The authors summarize the pertinent literature on the mechanical treatment of CV, focusing first on balloon angioplasty, second on therapy combined with intra-arterial drug infusion, and concluding by briefly discussing intra-aortic balloon counterpulsation. The epidemiology, pathophysiology, technique, outcome, timing and complications are discussed for each treatment option. Results: A review of the relevant medical literature reveals that in the last 20 years, endovascular techniques including transluminal balloon angioplasty, intra-arterial drug infusion and newer experimental strategies have provided an important supplement to the established medical therapy. Discussion: Despite these developments, however, CV remains a major contributor to poor outcome following aSAH and continued efforts are necessary to improve and refine endovascular strategies as well as develop new treatment modalities.

Original languageEnglish (US)
Pages (from-to)638-643
Number of pages6
JournalNeurological Research
Volume31
Issue number6
DOIs
StatePublished - Jul 1 2009
Externally publishedYes

Keywords

  • Angioplasty
  • Endovascular treatment
  • Subarachnoid hemorrhage
  • Vasospasm

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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    Haque, R., Kellner, C. P., Komotar, R. J., Connolly, E. S., Lavine, S. D., Solomon, R. A., & Meyers, P. M. (2009). Mechanical treatment of vasospasm. Neurological Research, 31(6), 638-643. https://doi.org/10.1179/174313209X455745