Abstract
Nicotine increases peak active isometric force in sham operated and RVH ventricular muscles by indirect (catecholamine mediated) and direct effects. In such muscles, action potential plateau and action potential duration lengthen in the course of time during exposure to nicotine (6.2 X 10-4 M and 6.2 X 10-3 M). Muscles from cats in overt right ventricular failure (RVF) showed significantly smaller transient positive inotropic responses during exposure to nicotine than sham and RVH muscles. RVF muscles demonstrated an increased maintained peak active force during exposure to 6.2 X 10-3 M nicotine.
| Original language | English |
|---|---|
| Pages (from-to) | 132-136 |
| Number of pages | 5 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 146 |
| Issue number | 1 |
| State | Published - Dec 1 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Mechanical and electrical actions of nicotine on hypertrophied and failed cat ventricle. / Bassett, A. L.; Wiggins, J. R.; Gelband, H.
In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 146, No. 1, 01.12.1974, p. 132-136.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanical and electrical actions of nicotine on hypertrophied and failed cat ventricle
AU - Bassett, A. L.
AU - Wiggins, J. R.
AU - Gelband, H.
PY - 1974/12/1
Y1 - 1974/12/1
N2 - Nicotine increases peak active isometric force in sham operated and RVH ventricular muscles by indirect (catecholamine mediated) and direct effects. In such muscles, action potential plateau and action potential duration lengthen in the course of time during exposure to nicotine (6.2 X 10-4 M and 6.2 X 10-3 M). Muscles from cats in overt right ventricular failure (RVF) showed significantly smaller transient positive inotropic responses during exposure to nicotine than sham and RVH muscles. RVF muscles demonstrated an increased maintained peak active force during exposure to 6.2 X 10-3 M nicotine.
AB - Nicotine increases peak active isometric force in sham operated and RVH ventricular muscles by indirect (catecholamine mediated) and direct effects. In such muscles, action potential plateau and action potential duration lengthen in the course of time during exposure to nicotine (6.2 X 10-4 M and 6.2 X 10-3 M). Muscles from cats in overt right ventricular failure (RVF) showed significantly smaller transient positive inotropic responses during exposure to nicotine than sham and RVH muscles. RVF muscles demonstrated an increased maintained peak active force during exposure to 6.2 X 10-3 M nicotine.
UR - http://www.scopus.com/inward/record.url?scp=0016195174&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016195174&partnerID=8YFLogxK
M3 - Article
C2 - 4275073
AN - SCOPUS:0016195174
VL - 146
SP - 132
EP - 136
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
SN - 0037-9727
IS - 1
ER -