Mechanical and Electrical Actions of Nicotine on Hypertrophied and Failed Cat Ventricle

Arthur L. Bassett; Jay R. Wiggins; Henry Gelband

doi:10.3181/00379727-146-38057

Mechanical and Electrical Actions of Nicotine on Hypertrophied and Failed Cat Ventricle

Arthur L. Bassett, Jay R. Wiggins, Henry Gelband

Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Nicotine increases peak active isometric force in sham operated and RVH ventricular muscles by indirect (catecholamine mediated) and direct effects. In such muscles, action potential plateau and action potential duration lengthen in the course of time during exposure to nicotine (6.2 X 10^-4 M and 6.2 X 10^-3 M). Muscles from cats in overt right ventricular failure (RVF) showed significantly smaller transient positive inotropic responses during exposure to nicotine than sham and RVH muscles. RVF muscles demonstrated an increased maintained peak active force during exposure to 6.2 X 10^-3 M nicotine.

Original language	English (US)
Pages (from-to)	132-136
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	146
Issue number	1
DOIs	https://doi.org/10.3181/00379727-146-38057
State	Published - May 1974

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Mechanical and Electrical Actions of Nicotine on Hypertrophied and Failed Cat Ventricle",

abstract = "Nicotine increases peak active isometric force in sham operated and RVH ventricular muscles by indirect (catecholamine mediated) and direct effects. In such muscles, action potential plateau and action potential duration lengthen in the course of time during exposure to nicotine (6.2 X 10-4 M and 6.2 X 10-3 M). Muscles from cats in overt right ventricular failure (RVF) showed significantly smaller transient positive inotropic responses during exposure to nicotine than sham and RVH muscles. RVF muscles demonstrated an increased maintained peak active force during exposure to 6.2 X 10-3 M nicotine.",

author = "Bassett, {Arthur L.} and Wiggins, {Jay R.} and Henry Gelband",

note = "Funding Information: This study was supported by a grant from the American Medical Association Education and Research Foundation and in part by NIH grant HL-12738-04. 2 ",

year = "1974",

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doi = "10.3181/00379727-146-38057",

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T1 - Mechanical and Electrical Actions of Nicotine on Hypertrophied and Failed Cat Ventricle

AU - Bassett, Arthur L.

AU - Wiggins, Jay R.

AU - Gelband, Henry

N1 - Funding Information: This study was supported by a grant from the American Medical Association Education and Research Foundation and in part by NIH grant HL-12738-04. 2

PY - 1974/5

Y1 - 1974/5

N2 - Nicotine increases peak active isometric force in sham operated and RVH ventricular muscles by indirect (catecholamine mediated) and direct effects. In such muscles, action potential plateau and action potential duration lengthen in the course of time during exposure to nicotine (6.2 X 10-4 M and 6.2 X 10-3 M). Muscles from cats in overt right ventricular failure (RVF) showed significantly smaller transient positive inotropic responses during exposure to nicotine than sham and RVH muscles. RVF muscles demonstrated an increased maintained peak active force during exposure to 6.2 X 10-3 M nicotine.

AB - Nicotine increases peak active isometric force in sham operated and RVH ventricular muscles by indirect (catecholamine mediated) and direct effects. In such muscles, action potential plateau and action potential duration lengthen in the course of time during exposure to nicotine (6.2 X 10-4 M and 6.2 X 10-3 M). Muscles from cats in overt right ventricular failure (RVF) showed significantly smaller transient positive inotropic responses during exposure to nicotine than sham and RVH muscles. RVF muscles demonstrated an increased maintained peak active force during exposure to 6.2 X 10-3 M nicotine.

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Mechanical and Electrical Actions of Nicotine on Hypertrophied and Failed Cat Ventricle

Abstract

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