Mechanical and electrical actions of nicotine on hypertrophied and failed cat ventricle

A. L. Bassett, J. R. Wiggins, H. Gelband

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Nicotine increases peak active isometric force in sham operated and RVH ventricular muscles by indirect (catecholamine mediated) and direct effects. In such muscles, action potential plateau and action potential duration lengthen in the course of time during exposure to nicotine (6.2 X 10-4 M and 6.2 X 10-3 M). Muscles from cats in overt right ventricular failure (RVF) showed significantly smaller transient positive inotropic responses during exposure to nicotine than sham and RVH muscles. RVF muscles demonstrated an increased maintained peak active force during exposure to 6.2 X 10-3 M nicotine.

Original languageEnglish
Pages (from-to)132-136
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume146
Issue number1
StatePublished - Dec 1 1974
Externally publishedYes

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Nicotine
Muscle
Cats
Muscles
Action Potentials
Catecholamines

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mechanical and electrical actions of nicotine on hypertrophied and failed cat ventricle. / Bassett, A. L.; Wiggins, J. R.; Gelband, H.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 146, No. 1, 01.12.1974, p. 132-136.

Research output: Contribution to journalArticle

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