Mechanical and Electrical Actions of Nicotine on Hypertrophied and Failed Cat Ventricle

Arthur L. Bassett, Jay R. Wiggins, Henry Gelband

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Nicotine increases peak active isometric force in sham operated and RVH ventricular muscles by indirect (catecholamine mediated) and direct effects. In such muscles, action potential plateau and action potential duration lengthen in the course of time during exposure to nicotine (6.2 X 10-4 M and 6.2 X 10-3 M). Muscles from cats in overt right ventricular failure (RVF) showed significantly smaller transient positive inotropic responses during exposure to nicotine than sham and RVH muscles. RVF muscles demonstrated an increased maintained peak active force during exposure to 6.2 X 10-3 M nicotine.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume146
Issue number1
DOIs
StatePublished - May 1974

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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