Abstract
Measurement of the ability of blood vessels to dilate and constrict, known as vascular reactivity, is often performed with breath-holding tasks that transiently raise arterial blood carbon dioxide (PaCO2) levels. However, following the proper commands for a breath-holding experiment may be difficult or impossible for many patients. In this study, we evaluated two approaches for obtaining vascular reactivity information using blood oxygenation level-dependent signal fluctuations obtained from resting-state functional magnetic resonance imaging data: physiological fluctuation regression and coefficient of variation of the resting-state functional magnetic resonance imaging signal. We studied a cohort of 28 older adults (69 ± 7 years) and found that six of them (21%) could not perform the breath-holding protocol, based on an objective comparison with an idealized respiratory waveform. In the subjects that could comply, we found a strong linear correlation between data extracted from spontaneous resting-state functional magnetic resonance imaging signal fluctuations and the blood oxygenation level-dependent percentage signal change during breath-holding challenge (R2= 0.57 and 0.61 for resting-state physiological fluctuation regression and resting-state coefficient of variation methods, respectively). This technique may eliminate the need for subject cooperation, thus allowing the evaluation of vascular reactivity in a wider range of clinical and research conditions in which it may otherwise be impractical.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2526-2538 |
| Number of pages | 13 |
| Journal | Journal of Cerebral Blood Flow and Metabolism |
| Volume | 37 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2017 |
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Keywords
- Blood oxygenation level-dependent contrast
- brain imaging
- breath-holding challenge
- cerebral hemodynamics
- cerebrospinal fluid
- cerebrovascular disease
- functional magnetic resonance imaging
- hemodynamics
- magnetic resonance
- magnetic resonance imaging
- resting state fMRI
- vascular cognitive impairment
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
Cite this
Measuring vascular reactivity with resting-state blood oxygenation level-dependent (BOLD) signal fluctuations : A potential alternative to the breath-holding challenge? / for the SPRINT Study Research Group.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 37, No. 7, 01.07.2017, p. 2526-2538.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Measuring vascular reactivity with resting-state blood oxygenation level-dependent (BOLD) signal fluctuations
T2 - A potential alternative to the breath-holding challenge?
AU - for the SPRINT Study Research Group
AU - Jahanian, Hesamoddin
AU - Christen, Thomas
AU - Moseley, Michael E.
AU - Pajewski, Nicholas M.
AU - Wright, Clinton B
AU - Tamura, Manjula K.
AU - Zaharchuk, Greg
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Measurement of the ability of blood vessels to dilate and constrict, known as vascular reactivity, is often performed with breath-holding tasks that transiently raise arterial blood carbon dioxide (PaCO2) levels. However, following the proper commands for a breath-holding experiment may be difficult or impossible for many patients. In this study, we evaluated two approaches for obtaining vascular reactivity information using blood oxygenation level-dependent signal fluctuations obtained from resting-state functional magnetic resonance imaging data: physiological fluctuation regression and coefficient of variation of the resting-state functional magnetic resonance imaging signal. We studied a cohort of 28 older adults (69 ± 7 years) and found that six of them (21%) could not perform the breath-holding protocol, based on an objective comparison with an idealized respiratory waveform. In the subjects that could comply, we found a strong linear correlation between data extracted from spontaneous resting-state functional magnetic resonance imaging signal fluctuations and the blood oxygenation level-dependent percentage signal change during breath-holding challenge (R2= 0.57 and 0.61 for resting-state physiological fluctuation regression and resting-state coefficient of variation methods, respectively). This technique may eliminate the need for subject cooperation, thus allowing the evaluation of vascular reactivity in a wider range of clinical and research conditions in which it may otherwise be impractical.
AB - Measurement of the ability of blood vessels to dilate and constrict, known as vascular reactivity, is often performed with breath-holding tasks that transiently raise arterial blood carbon dioxide (PaCO2) levels. However, following the proper commands for a breath-holding experiment may be difficult or impossible for many patients. In this study, we evaluated two approaches for obtaining vascular reactivity information using blood oxygenation level-dependent signal fluctuations obtained from resting-state functional magnetic resonance imaging data: physiological fluctuation regression and coefficient of variation of the resting-state functional magnetic resonance imaging signal. We studied a cohort of 28 older adults (69 ± 7 years) and found that six of them (21%) could not perform the breath-holding protocol, based on an objective comparison with an idealized respiratory waveform. In the subjects that could comply, we found a strong linear correlation between data extracted from spontaneous resting-state functional magnetic resonance imaging signal fluctuations and the blood oxygenation level-dependent percentage signal change during breath-holding challenge (R2= 0.57 and 0.61 for resting-state physiological fluctuation regression and resting-state coefficient of variation methods, respectively). This technique may eliminate the need for subject cooperation, thus allowing the evaluation of vascular reactivity in a wider range of clinical and research conditions in which it may otherwise be impractical.
KW - Blood oxygenation level-dependent contrast
KW - brain imaging
KW - breath-holding challenge
KW - cerebral hemodynamics
KW - cerebrospinal fluid
KW - cerebrovascular disease
KW - functional magnetic resonance imaging
KW - hemodynamics
KW - magnetic resonance
KW - magnetic resonance imaging
KW - resting state fMRI
KW - vascular cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85021158709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021158709&partnerID=8YFLogxK
U2 - 10.1177/0271678X16670921
DO - 10.1177/0271678X16670921
M3 - Article
C2 - 27683452
AN - SCOPUS:85021158709
VL - 37
SP - 2526
EP - 2538
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 7
ER -