Measuring vascular reactivity with resting-state blood oxygenation level-dependent (BOLD) signal fluctuations: A potential alternative to the breath-holding challenge?

for the SPRINT Study Research Group

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Measurement of the ability of blood vessels to dilate and constrict, known as vascular reactivity, is often performed with breath-holding tasks that transiently raise arterial blood carbon dioxide (PaCO2) levels. However, following the proper commands for a breath-holding experiment may be difficult or impossible for many patients. In this study, we evaluated two approaches for obtaining vascular reactivity information using blood oxygenation level-dependent signal fluctuations obtained from resting-state functional magnetic resonance imaging data: physiological fluctuation regression and coefficient of variation of the resting-state functional magnetic resonance imaging signal. We studied a cohort of 28 older adults (69 ± 7 years) and found that six of them (21%) could not perform the breath-holding protocol, based on an objective comparison with an idealized respiratory waveform. In the subjects that could comply, we found a strong linear correlation between data extracted from spontaneous resting-state functional magnetic resonance imaging signal fluctuations and the blood oxygenation level-dependent percentage signal change during breath-holding challenge (R2= 0.57 and 0.61 for resting-state physiological fluctuation regression and resting-state coefficient of variation methods, respectively). This technique may eliminate the need for subject cooperation, thus allowing the evaluation of vascular reactivity in a wider range of clinical and research conditions in which it may otherwise be impractical.

Original languageEnglish (US)
Pages (from-to)2526-2538
Number of pages13
JournalJournal of Cerebral Blood Flow and Metabolism
Volume37
Issue number7
DOIs
StatePublished - Jul 1 2017

Keywords

  • Blood oxygenation level-dependent contrast
  • brain imaging
  • breath-holding challenge
  • cerebral hemodynamics
  • cerebrospinal fluid
  • cerebrovascular disease
  • functional magnetic resonance imaging
  • hemodynamics
  • magnetic resonance
  • magnetic resonance imaging
  • resting state fMRI
  • vascular cognitive impairment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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