Measuring vascular reactivity with resting-state blood oxygenation level-dependent (BOLD) signal fluctuations: A potential alternative to the breath-holding challenge?

for the SPRINT Study Research Group

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Measurement of the ability of blood vessels to dilate and constrict, known as vascular reactivity, is often performed with breath-holding tasks that transiently raise arterial blood carbon dioxide (PaCO2) levels. However, following the proper commands for a breath-holding experiment may be difficult or impossible for many patients. In this study, we evaluated two approaches for obtaining vascular reactivity information using blood oxygenation level-dependent signal fluctuations obtained from resting-state functional magnetic resonance imaging data: physiological fluctuation regression and coefficient of variation of the resting-state functional magnetic resonance imaging signal. We studied a cohort of 28 older adults (69 ± 7 years) and found that six of them (21%) could not perform the breath-holding protocol, based on an objective comparison with an idealized respiratory waveform. In the subjects that could comply, we found a strong linear correlation between data extracted from spontaneous resting-state functional magnetic resonance imaging signal fluctuations and the blood oxygenation level-dependent percentage signal change during breath-holding challenge (R2= 0.57 and 0.61 for resting-state physiological fluctuation regression and resting-state coefficient of variation methods, respectively). This technique may eliminate the need for subject cooperation, thus allowing the evaluation of vascular reactivity in a wider range of clinical and research conditions in which it may otherwise be impractical.

Original languageEnglish (US)
Pages (from-to)2526-2538
Number of pages13
JournalJournal of Cerebral Blood Flow and Metabolism
Volume37
Issue number7
DOIs
StatePublished - Jul 1 2017

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Breath Holding
Blood Vessels
Magnetic Resonance Imaging
Carbon Dioxide
Research

Keywords

  • Blood oxygenation level-dependent contrast
  • brain imaging
  • breath-holding challenge
  • cerebral hemodynamics
  • cerebrospinal fluid
  • cerebrovascular disease
  • functional magnetic resonance imaging
  • hemodynamics
  • magnetic resonance
  • magnetic resonance imaging
  • resting state fMRI
  • vascular cognitive impairment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Measuring vascular reactivity with resting-state blood oxygenation level-dependent (BOLD) signal fluctuations: A potential alternative to the breath-holding challenge?",
abstract = "Measurement of the ability of blood vessels to dilate and constrict, known as vascular reactivity, is often performed with breath-holding tasks that transiently raise arterial blood carbon dioxide (PaCO2) levels. However, following the proper commands for a breath-holding experiment may be difficult or impossible for many patients. In this study, we evaluated two approaches for obtaining vascular reactivity information using blood oxygenation level-dependent signal fluctuations obtained from resting-state functional magnetic resonance imaging data: physiological fluctuation regression and coefficient of variation of the resting-state functional magnetic resonance imaging signal. We studied a cohort of 28 older adults (69 ± 7 years) and found that six of them (21{\%}) could not perform the breath-holding protocol, based on an objective comparison with an idealized respiratory waveform. In the subjects that could comply, we found a strong linear correlation between data extracted from spontaneous resting-state functional magnetic resonance imaging signal fluctuations and the blood oxygenation level-dependent percentage signal change during breath-holding challenge (R2= 0.57 and 0.61 for resting-state physiological fluctuation regression and resting-state coefficient of variation methods, respectively). This technique may eliminate the need for subject cooperation, thus allowing the evaluation of vascular reactivity in a wider range of clinical and research conditions in which it may otherwise be impractical.",
keywords = "Blood oxygenation level-dependent contrast, brain imaging, breath-holding challenge, cerebral hemodynamics, cerebrospinal fluid, cerebrovascular disease, functional magnetic resonance imaging, hemodynamics, magnetic resonance, magnetic resonance imaging, resting state fMRI, vascular cognitive impairment",
author = "{for the SPRINT Study Research Group} and Hesamoddin Jahanian and Thomas Christen and Moseley, {Michael E.} and Pajewski, {Nicholas M.} and Wright, {Clinton B} and Tamura, {Manjula K.} and Greg Zaharchuk",
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T1 - Measuring vascular reactivity with resting-state blood oxygenation level-dependent (BOLD) signal fluctuations

T2 - A potential alternative to the breath-holding challenge?

AU - for the SPRINT Study Research Group

AU - Jahanian, Hesamoddin

AU - Christen, Thomas

AU - Moseley, Michael E.

AU - Pajewski, Nicholas M.

AU - Wright, Clinton B

AU - Tamura, Manjula K.

AU - Zaharchuk, Greg

PY - 2017/7/1

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N2 - Measurement of the ability of blood vessels to dilate and constrict, known as vascular reactivity, is often performed with breath-holding tasks that transiently raise arterial blood carbon dioxide (PaCO2) levels. However, following the proper commands for a breath-holding experiment may be difficult or impossible for many patients. In this study, we evaluated two approaches for obtaining vascular reactivity information using blood oxygenation level-dependent signal fluctuations obtained from resting-state functional magnetic resonance imaging data: physiological fluctuation regression and coefficient of variation of the resting-state functional magnetic resonance imaging signal. We studied a cohort of 28 older adults (69 ± 7 years) and found that six of them (21%) could not perform the breath-holding protocol, based on an objective comparison with an idealized respiratory waveform. In the subjects that could comply, we found a strong linear correlation between data extracted from spontaneous resting-state functional magnetic resonance imaging signal fluctuations and the blood oxygenation level-dependent percentage signal change during breath-holding challenge (R2= 0.57 and 0.61 for resting-state physiological fluctuation regression and resting-state coefficient of variation methods, respectively). This technique may eliminate the need for subject cooperation, thus allowing the evaluation of vascular reactivity in a wider range of clinical and research conditions in which it may otherwise be impractical.

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KW - Blood oxygenation level-dependent contrast

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KW - breath-holding challenge

KW - cerebral hemodynamics

KW - cerebrospinal fluid

KW - cerebrovascular disease

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KW - hemodynamics

KW - magnetic resonance

KW - magnetic resonance imaging

KW - resting state fMRI

KW - vascular cognitive impairment

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