Measuring the three-dimensional structural properties of topologically associating domains

Tong Liu; Zheng Wang

doi:10.1109/BIBM.2018.8621459

Measuring the three-dimensional structural properties of topologically associating domains

Tong Liu, Zheng Wang

Computer Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Genome topologically associating domains (TADs) are mega base pair (Mbp) sized genomic regions that may be the structural and functional units of the genome. To better understand their structural properties and the relationship between structural properties and genetic and epigenetic features, we designed and benchmarked two measures to capture the three-dimensional structural signature of TADs. We modified the original definition of radius of gyration so that it could measure the spatial compactness of TADs weighted by one or more genetic or epigenetic feature(s). Another structural measure we have benchmarked is folding degree. We found correlations between structural measures and genetic and epigenetic features. We obtained similar correlations if considering the spatial compactness of the DNA segments containing transcription start sites, RNA polymerase II, and H3K4me3 peaks. Moreover, we designed a new objective function for reconstructing chromosome 3D structures using multidimensional scaling and compared it with two existent objective functions. The three objective functions have been implemented as web-based and standalone tools. The web server and source code are available at http://dna.cs.miami.edu/3DChrom/.

Original language	English (US)
Title of host publication	Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
Editors	Harald Schmidt, David Griol, Haiying Wang, Jan Baumbach, Huiru Zheng, Zoraida Callejas, Xiaohua Hu, Julie Dickerson, Le Zhang
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	21-28
Number of pages	8
ISBN (Electronic)	9781538654880
DOIs	https://doi.org/10.1109/BIBM.2018.8621459
State	Published - Jan 21 2019
Event	2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 - Madrid, Spain Duration: Dec 3 2018 → Dec 6 2018

Publication series

Name	Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

Conference

Conference	2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
Country	Spain
City	Madrid
Period	12/3/18 → 12/6/18

Keywords

3D genome
Hi-C
Structural Properties.
Topologically Associating Domains

ASJC Scopus subject areas

Biomedical Engineering
Health Informatics

Access to Document

10.1109/BIBM.2018.8621459

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Liu, T., & Wang, Z. (2019). Measuring the three-dimensional structural properties of topologically associating domains. In H. Schmidt, D. Griol, H. Wang, J. Baumbach, H. Zheng, Z. Callejas, X. Hu, J. Dickerson, & L. Zhang (Eds.), Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 (pp. 21-28). [8621459] (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2018.8621459

Measuring the three-dimensional structural properties of topologically associating domains. / Liu, Tong; Wang, Zheng.

Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. ed. / Harald Schmidt; David Griol; Haiying Wang; Jan Baumbach; Huiru Zheng; Zoraida Callejas; Xiaohua Hu; Julie Dickerson; Le Zhang. Institute of Electrical and Electronics Engineers Inc., 2019. p. 21-28 8621459 (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Liu, T & Wang, Z 2019, Measuring the three-dimensional structural properties of topologically associating domains. in H Schmidt, D Griol, H Wang, J Baumbach, H Zheng, Z Callejas, X Hu, J Dickerson & L Zhang (eds), Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018., 8621459, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018, Institute of Electrical and Electronics Engineers Inc., pp. 21-28, 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018, Madrid, Spain, 12/3/18. https://doi.org/10.1109/BIBM.2018.8621459

Liu T, Wang Z. Measuring the three-dimensional structural properties of topologically associating domains. In Schmidt H, Griol D, Wang H, Baumbach J, Zheng H, Callejas Z, Hu X, Dickerson J, Zhang L, editors, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. Institute of Electrical and Electronics Engineers Inc. 2019. p. 21-28. 8621459. (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018). https://doi.org/10.1109/BIBM.2018.8621459

Liu, Tong ; Wang, Zheng. / Measuring the three-dimensional structural properties of topologically associating domains. Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. editor / Harald Schmidt ; David Griol ; Haiying Wang ; Jan Baumbach ; Huiru Zheng ; Zoraida Callejas ; Xiaohua Hu ; Julie Dickerson ; Le Zhang. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 21-28 (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).

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