Measuring the depth of perineural invasion in cutaneous squamous cell carcinoma: Implications for biopsy technique

Jennifer C. Tang, Seung David L. Kim, Erik J. Stratman

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

BACKGROUND Perineural invasion (PNI) is a high-risk feature of cutaneous squamous cell carcinoma (CSCC). Depths at which PNI occurs are unknown. OBJECTIVE To determine the most superficial depth at which PNI occurs in CSCC and stratify by tumor clinical diameter and body location. METHODS AND MATERIALS Single-institution retrospective review of CSCC specimens reporting PNI on pathology reports between January 2004 and August 2014. Depth was defined as distance from top of granular layer to middle of nerve invaded by CSCC or distance from erosion to middle of nerve affected by CSCC. RESULTS Of 66 specimens identified with PNI, 45 specimens were included. Mean histopathologic depth to PNI was 2.7 mm (SD = 1.8 mm, median depth = 2.2 mm, range 0.5-12 mm). Perineural invasion depth varied by anatomic location, with the head associated with most superficial average PNI depth (2.2 mm) and trunk with greatest average PNI depth (4.3 mm). Perineural invasion depth correlated with clinical tumor diameter. The largest percentage of specimens with PNI were of clinical diameter of at least 2 cm (20/45 = 44%). CONCLUSION Clinicians encountering lesions suspicious for CSCC have the greatest chance of detecting PNI using biopsy techniques that reach at least 3 to 4 mm deep.

Original languageEnglish (US)
Pages (from-to)1170-1173
Number of pages4
JournalDermatologic Surgery
Volume44
Issue number9
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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