Measuring ocular characteristics after Gel Injection Adjustable Keratoplasty (GIAK) in the rabbit

Jason I. Comander, Jean Marie Parel, Gabriel Simon, Yoshiko Takesue, Franck Villain

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


Gel Injection Adjustable Keratoplasty (GIAK) is a refractive surgery procedure which uses an ocular ring implant made of a polyethylene oxide hydrogel to cause a refractive change in the cornea. Unlike laser photo refractive keratectomy (PRK), GIAK does not interfere with the central cornea because the ring lies around the optical axis. Thus, vision can be assessed immediately after surgery. Our in vivo study was designed to quantify GIAK's effects on tissues, the btocompatibility of the polymer and in the process investigate which ocular changes in the rabbit model can be monitored with precision using current technology. Thirty-two young rabbits underwent a delamination in one eye, 22 of which were injected with a new polymeric gel. Corneal topography, keratometry, pachymetry, and tonometry were performed on both eyes for up to 105 days. All corneas flattened with growth. In GIAK animals, we found an average flattening of 6.51 ±1.23 diopters (p<0.0001) relative to the fellow eye. No statistically significant regression over the 102 days was observed. Intraocular pressure dropped slightly by 0.69±1.21 mmHg (p=0.025), a clinically insignificant value, while no significant change was detected in corneal thickness. Keratometry can be tracked in rabbits after GIAK surgery from POD 1. Measuring unoperated fellow eyes allows for the effects of surgery to be assessed without bias from growth. Using this protocol, GIAK was shown to be stable. It was more difficult to draw conclusions from pachymetry, tonometry, and topography data.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - May 22 1995
EventOphthalmic Technologies V 1995 - San Jose, United States
Duration: Feb 1 1995Feb 28 1995

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


Dive into the research topics of 'Measuring ocular characteristics after Gel Injection Adjustable Keratoplasty (GIAK) in the rabbit'. Together they form a unique fingerprint.

Cite this