Measuring epileptogenicity in kainic acid injected rats

Karin H. Somerlik, Delphine Cosandier-Rimele, Joacir G. Cordeiro, Thilo B. Kruger, Rudi Mattmuller, Thomas Stieglitz, Ad Aertsen, Andreas Schulze-Bonhage

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

The present work aims at improving the validation of therapeutic approaches to treat temporal lobe epilepsy. Today's antiepileptic drugs perform only poorly for this form of epilepsy, and electrical stimulation might be an alternative for these patients. Finding the optimal stimulation parameters, however, is difficult as the underlying mechanisms, both of the disease and the stimulation procedure, and even the evaluation of the therapeutic effect are still poorly understood. Here we used a method to obtain a quantitative measure the relative phase clustering index (rPCI) of the epileptogenicity of a brain region in a simple and straightforward way.

Original languageEnglish (US)
Title of host publication2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
Pages188-191
Number of pages4
DOIs
StatePublished - 2011
Externally publishedYes
Event2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011 - Cancun, Mexico
Duration: Apr 27 2011May 1 2011

Publication series

Name2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011

Other

Other2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
Country/TerritoryMexico
CityCancun
Period4/27/115/1/11

ASJC Scopus subject areas

  • Neuroscience(all)

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