Abstract
Background: Adiposity may increase risk for dementia and Alzheimer's disease (AD), but mechanisms are unclear. Objective: To examine associations between measures of adiposity with AD-signature region cortical thickness and hippocampal volume. Methods: We used data from the Northern Manhattan Study, a clinically stroke-free cohort of mostly Hispanic participants. Exposures of interest included body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC), and adiponectin concentration, measured at study entry. AD-signature region cortical thickness and hippocampal volume were obtained using Freesurfer. We estimated associations using multivariable linear regression, adjusting for sociodemographics and health behaviors. We re-examined estimates after adjustment for APOE ϵ4 allele status or carotid intima-media thickness (cIMT), among those cognitively unimpaired, and after weighting for the inverse probability of selection into the MRI sub-study. We also repeated analyses for cortical thickness in non-AD signature regions. Results: The sample (N = 947, 63% women, 66% Hispanic/Latino, 26% obese) had a mean (SD) age = 63 (8) years. Greater BMI and WC (both z-scored) were associated with thinner AD-signature region cortex (also z-scored) (BMI: β [95% CI] = -0.09 [-0.18, -0.01], WC: β [95% CI] = -0.11 [-0.20, -0.02]). We did not find evidence that adiposity was related to hippocampal volume. Results were consistent after adjustment for APOE ϵ4 allele status or cIMT, after weighting for selection, among those cognitively unimpaired, and for non-AD signature region cortical thickness. Conclusion: Greater BMI and WC were related to cortical thinning within and outside the AD-signature region, suggesting a global effect not specific to AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 995-1004 |
| Number of pages | 10 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 70 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Adiposity
- brain aging
- epidemiology
- neuroimaging
- structural MRI
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Measures of Adiposity and Alzheimer's Disease-Related MRI Markers : The Northern Manhattan Study. / Caunca, Michelle R.; Simonetto, Marialaura; Alperin, Noam; Elkind, Mitchell S.V.; Sacco, Ralph L.; Wright, Clinton B.; Rundek, Tatjana.
In: Journal of Alzheimer's Disease, Vol. 70, No. 4, 01.01.2019, p. 995-1004.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Measures of Adiposity and Alzheimer's Disease-Related MRI Markers
T2 - The Northern Manhattan Study
AU - Caunca, Michelle R.
AU - Simonetto, Marialaura
AU - Alperin, Noam
AU - Elkind, Mitchell S.V.
AU - Sacco, Ralph L.
AU - Wright, Clinton B.
AU - Rundek, Tatjana
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Adiposity may increase risk for dementia and Alzheimer's disease (AD), but mechanisms are unclear. Objective: To examine associations between measures of adiposity with AD-signature region cortical thickness and hippocampal volume. Methods: We used data from the Northern Manhattan Study, a clinically stroke-free cohort of mostly Hispanic participants. Exposures of interest included body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC), and adiponectin concentration, measured at study entry. AD-signature region cortical thickness and hippocampal volume were obtained using Freesurfer. We estimated associations using multivariable linear regression, adjusting for sociodemographics and health behaviors. We re-examined estimates after adjustment for APOE ϵ4 allele status or carotid intima-media thickness (cIMT), among those cognitively unimpaired, and after weighting for the inverse probability of selection into the MRI sub-study. We also repeated analyses for cortical thickness in non-AD signature regions. Results: The sample (N = 947, 63% women, 66% Hispanic/Latino, 26% obese) had a mean (SD) age = 63 (8) years. Greater BMI and WC (both z-scored) were associated with thinner AD-signature region cortex (also z-scored) (BMI: β [95% CI] = -0.09 [-0.18, -0.01], WC: β [95% CI] = -0.11 [-0.20, -0.02]). We did not find evidence that adiposity was related to hippocampal volume. Results were consistent after adjustment for APOE ϵ4 allele status or cIMT, after weighting for selection, among those cognitively unimpaired, and for non-AD signature region cortical thickness. Conclusion: Greater BMI and WC were related to cortical thinning within and outside the AD-signature region, suggesting a global effect not specific to AD.
AB - Background: Adiposity may increase risk for dementia and Alzheimer's disease (AD), but mechanisms are unclear. Objective: To examine associations between measures of adiposity with AD-signature region cortical thickness and hippocampal volume. Methods: We used data from the Northern Manhattan Study, a clinically stroke-free cohort of mostly Hispanic participants. Exposures of interest included body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC), and adiponectin concentration, measured at study entry. AD-signature region cortical thickness and hippocampal volume were obtained using Freesurfer. We estimated associations using multivariable linear regression, adjusting for sociodemographics and health behaviors. We re-examined estimates after adjustment for APOE ϵ4 allele status or carotid intima-media thickness (cIMT), among those cognitively unimpaired, and after weighting for the inverse probability of selection into the MRI sub-study. We also repeated analyses for cortical thickness in non-AD signature regions. Results: The sample (N = 947, 63% women, 66% Hispanic/Latino, 26% obese) had a mean (SD) age = 63 (8) years. Greater BMI and WC (both z-scored) were associated with thinner AD-signature region cortex (also z-scored) (BMI: β [95% CI] = -0.09 [-0.18, -0.01], WC: β [95% CI] = -0.11 [-0.20, -0.02]). We did not find evidence that adiposity was related to hippocampal volume. Results were consistent after adjustment for APOE ϵ4 allele status or cIMT, after weighting for selection, among those cognitively unimpaired, and for non-AD signature region cortical thickness. Conclusion: Greater BMI and WC were related to cortical thinning within and outside the AD-signature region, suggesting a global effect not specific to AD.
KW - Adiposity
KW - brain aging
KW - epidemiology
KW - neuroimaging
KW - structural MRI
UR - http://www.scopus.com/inward/record.url?scp=85071259820&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071259820&partnerID=8YFLogxK
U2 - 10.3233/JAD-190092
DO - 10.3233/JAD-190092
M3 - Article
C2 - 31306120
AN - SCOPUS:85071259820
VL - 70
SP - 995
EP - 1004
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 4
ER -