Measures of Adiposity and Alzheimer's Disease-Related MRI Markers: The Northern Manhattan Study

Michelle R. Caunca, Marialaura Simonetto, Noam Alperin, Mitchell S.V. Elkind, Ralph L. Sacco, Clinton B. Wright, Tatjana Rundek

Research output: Contribution to journalArticle

Abstract

Background: Adiposity may increase risk for dementia and Alzheimer's disease (AD), but mechanisms are unclear. Objective: To examine associations between measures of adiposity with AD-signature region cortical thickness and hippocampal volume. Methods: We used data from the Northern Manhattan Study, a clinically stroke-free cohort of mostly Hispanic participants. Exposures of interest included body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC), and adiponectin concentration, measured at study entry. AD-signature region cortical thickness and hippocampal volume were obtained using Freesurfer. We estimated associations using multivariable linear regression, adjusting for sociodemographics and health behaviors. We re-examined estimates after adjustment for APOE ϵ4 allele status or carotid intima-media thickness (cIMT), among those cognitively unimpaired, and after weighting for the inverse probability of selection into the MRI sub-study. We also repeated analyses for cortical thickness in non-AD signature regions. Results: The sample (N = 947, 63% women, 66% Hispanic/Latino, 26% obese) had a mean (SD) age = 63 (8) years. Greater BMI and WC (both z-scored) were associated with thinner AD-signature region cortex (also z-scored) (BMI: β [95% CI] = -0.09 [-0.18, -0.01], WC: β [95% CI] = -0.11 [-0.20, -0.02]). We did not find evidence that adiposity was related to hippocampal volume. Results were consistent after adjustment for APOE ϵ4 allele status or cIMT, after weighting for selection, among those cognitively unimpaired, and for non-AD signature region cortical thickness. Conclusion: Greater BMI and WC were related to cortical thinning within and outside the AD-signature region, suggesting a global effect not specific to AD.

Original languageEnglish (US)
Pages (from-to)995-1004
Number of pages10
JournalJournal of Alzheimer's Disease
Volume70
Issue number4
DOIs
StatePublished - Jan 1 2019

Fingerprint

Adiposity
Alzheimer Disease
Waist Circumference
Body Mass Index
Hispanic Americans
Carotid Intima-Media Thickness
Alleles
Waist-Hip Ratio
Adiponectin
Health Behavior
Dementia
Linear Models
Stroke

Keywords

  • Adiposity
  • brain aging
  • epidemiology
  • neuroimaging
  • structural MRI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Measures of Adiposity and Alzheimer's Disease-Related MRI Markers : The Northern Manhattan Study. / Caunca, Michelle R.; Simonetto, Marialaura; Alperin, Noam; Elkind, Mitchell S.V.; Sacco, Ralph L.; Wright, Clinton B.; Rundek, Tatjana.

In: Journal of Alzheimer's Disease, Vol. 70, No. 4, 01.01.2019, p. 995-1004.

Research output: Contribution to journalArticle

Caunca, Michelle R. ; Simonetto, Marialaura ; Alperin, Noam ; Elkind, Mitchell S.V. ; Sacco, Ralph L. ; Wright, Clinton B. ; Rundek, Tatjana. / Measures of Adiposity and Alzheimer's Disease-Related MRI Markers : The Northern Manhattan Study. In: Journal of Alzheimer's Disease. 2019 ; Vol. 70, No. 4. pp. 995-1004.
@article{0822d4366f8e48c992f34ac4e5740d16,
title = "Measures of Adiposity and Alzheimer's Disease-Related MRI Markers: The Northern Manhattan Study",
abstract = "Background: Adiposity may increase risk for dementia and Alzheimer's disease (AD), but mechanisms are unclear. Objective: To examine associations between measures of adiposity with AD-signature region cortical thickness and hippocampal volume. Methods: We used data from the Northern Manhattan Study, a clinically stroke-free cohort of mostly Hispanic participants. Exposures of interest included body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC), and adiponectin concentration, measured at study entry. AD-signature region cortical thickness and hippocampal volume were obtained using Freesurfer. We estimated associations using multivariable linear regression, adjusting for sociodemographics and health behaviors. We re-examined estimates after adjustment for APOE ϵ4 allele status or carotid intima-media thickness (cIMT), among those cognitively unimpaired, and after weighting for the inverse probability of selection into the MRI sub-study. We also repeated analyses for cortical thickness in non-AD signature regions. Results: The sample (N = 947, 63{\%} women, 66{\%} Hispanic/Latino, 26{\%} obese) had a mean (SD) age = 63 (8) years. Greater BMI and WC (both z-scored) were associated with thinner AD-signature region cortex (also z-scored) (BMI: β [95{\%} CI] = -0.09 [-0.18, -0.01], WC: β [95{\%} CI] = -0.11 [-0.20, -0.02]). We did not find evidence that adiposity was related to hippocampal volume. Results were consistent after adjustment for APOE ϵ4 allele status or cIMT, after weighting for selection, among those cognitively unimpaired, and for non-AD signature region cortical thickness. Conclusion: Greater BMI and WC were related to cortical thinning within and outside the AD-signature region, suggesting a global effect not specific to AD.",
keywords = "Adiposity, brain aging, epidemiology, neuroimaging, structural MRI",
author = "Caunca, {Michelle R.} and Marialaura Simonetto and Noam Alperin and Elkind, {Mitchell S.V.} and Sacco, {Ralph L.} and Wright, {Clinton B.} and Tatjana Rundek",
year = "2019",
month = "1",
day = "1",
doi = "10.3233/JAD-190092",
language = "English (US)",
volume = "70",
pages = "995--1004",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "4",

}

TY - JOUR

T1 - Measures of Adiposity and Alzheimer's Disease-Related MRI Markers

T2 - The Northern Manhattan Study

AU - Caunca, Michelle R.

AU - Simonetto, Marialaura

AU - Alperin, Noam

AU - Elkind, Mitchell S.V.

AU - Sacco, Ralph L.

AU - Wright, Clinton B.

AU - Rundek, Tatjana

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Adiposity may increase risk for dementia and Alzheimer's disease (AD), but mechanisms are unclear. Objective: To examine associations between measures of adiposity with AD-signature region cortical thickness and hippocampal volume. Methods: We used data from the Northern Manhattan Study, a clinically stroke-free cohort of mostly Hispanic participants. Exposures of interest included body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC), and adiponectin concentration, measured at study entry. AD-signature region cortical thickness and hippocampal volume were obtained using Freesurfer. We estimated associations using multivariable linear regression, adjusting for sociodemographics and health behaviors. We re-examined estimates after adjustment for APOE ϵ4 allele status or carotid intima-media thickness (cIMT), among those cognitively unimpaired, and after weighting for the inverse probability of selection into the MRI sub-study. We also repeated analyses for cortical thickness in non-AD signature regions. Results: The sample (N = 947, 63% women, 66% Hispanic/Latino, 26% obese) had a mean (SD) age = 63 (8) years. Greater BMI and WC (both z-scored) were associated with thinner AD-signature region cortex (also z-scored) (BMI: β [95% CI] = -0.09 [-0.18, -0.01], WC: β [95% CI] = -0.11 [-0.20, -0.02]). We did not find evidence that adiposity was related to hippocampal volume. Results were consistent after adjustment for APOE ϵ4 allele status or cIMT, after weighting for selection, among those cognitively unimpaired, and for non-AD signature region cortical thickness. Conclusion: Greater BMI and WC were related to cortical thinning within and outside the AD-signature region, suggesting a global effect not specific to AD.

AB - Background: Adiposity may increase risk for dementia and Alzheimer's disease (AD), but mechanisms are unclear. Objective: To examine associations between measures of adiposity with AD-signature region cortical thickness and hippocampal volume. Methods: We used data from the Northern Manhattan Study, a clinically stroke-free cohort of mostly Hispanic participants. Exposures of interest included body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC), and adiponectin concentration, measured at study entry. AD-signature region cortical thickness and hippocampal volume were obtained using Freesurfer. We estimated associations using multivariable linear regression, adjusting for sociodemographics and health behaviors. We re-examined estimates after adjustment for APOE ϵ4 allele status or carotid intima-media thickness (cIMT), among those cognitively unimpaired, and after weighting for the inverse probability of selection into the MRI sub-study. We also repeated analyses for cortical thickness in non-AD signature regions. Results: The sample (N = 947, 63% women, 66% Hispanic/Latino, 26% obese) had a mean (SD) age = 63 (8) years. Greater BMI and WC (both z-scored) were associated with thinner AD-signature region cortex (also z-scored) (BMI: β [95% CI] = -0.09 [-0.18, -0.01], WC: β [95% CI] = -0.11 [-0.20, -0.02]). We did not find evidence that adiposity was related to hippocampal volume. Results were consistent after adjustment for APOE ϵ4 allele status or cIMT, after weighting for selection, among those cognitively unimpaired, and for non-AD signature region cortical thickness. Conclusion: Greater BMI and WC were related to cortical thinning within and outside the AD-signature region, suggesting a global effect not specific to AD.

KW - Adiposity

KW - brain aging

KW - epidemiology

KW - neuroimaging

KW - structural MRI

UR - http://www.scopus.com/inward/record.url?scp=85071259820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071259820&partnerID=8YFLogxK

U2 - 10.3233/JAD-190092

DO - 10.3233/JAD-190092

M3 - Article

C2 - 31306120

AN - SCOPUS:85071259820

VL - 70

SP - 995

EP - 1004

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 4

ER -