Measurement of ion diffusivity in intervertebral disc using a two-point electrical conductivity approach

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The intervertebral disc (IVD) is an avascular structure, relying on diffusion for cellular nutrition. Therefore, understanding transport in IVD tissue is important for elucidating mechanisms and pathways of nutritional supply to the disc. Here, a new two-point electrical conductivity approach to measuring the diffusivity of ions in IVD tissues was developed. In order to test the reliability of this method, the Cl- ion diffusivity in bovine annulus fibrosus (AF) and nucleus pulposus (NP) tissues was determined. For AF, the Cl- ion diffusivity was measured as 7.56 ± 2.12 x 10 -∈10 m2/sec (n=15), while that in NP was 1.03 ± 0.16 x 10-∈9 m2/sec (n=15). Results found here are in agreement with those in the literature for ion diffusion in IVD tissues, indicating this new method can reliably measure ion diffusivity in IVD tissues.

Original languageEnglish (US)
Title of host publication25th Southern Biomedical Engineering Conference 2009
Pages171-172
Number of pages2
DOIs
StatePublished - Nov 6 2009
Event25th Southern Biomedical Engineering Conference 2009 - Miami, FL, United States
Duration: May 15 2009May 17 2009

Publication series

NameIFMBE Proceedings
Volume24
ISSN (Print)1680-0737

Other

Other25th Southern Biomedical Engineering Conference 2009
CountryUnited States
CityMiami, FL
Period5/15/095/17/09

Keywords

  • Annulus fibrosus
  • Diffusion
  • Fixed charge density
  • Nucleus pulposus
  • Transport

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

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