Measurement of heart rate variability

A clinical tool or a research toy?

Heikki V. Huikuri, Timo Mäkikallio, K. E Juhani Airaksinen, Raul Mitrani, Agustin Castellanos, Robert J Myerburg

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

The objectives of this review are to discuss the diversity of mechanisms that may explain the association between heart rate (HR) variability and mortality, to appraise the clinical applicability of traditional and new measures of HR variability and to propose future directions in this field of research. There is a large body of data demonstrating that abnormal HR variability measured over a 24-h period provides information on the risk of subsequent death in subjects with and without structural heart disease. However, the mechanisms responsible for this association are not completely established. Therefore, no specific therapy is currently available to improve the prognosis for patients with abnormal HR variability. Reduced HR variability has been most commonly associated with a risk of arrhythmic death, but recent data suggest that abnormal variability also predicts vascular causes of death, progression of coronary atherosclerosis and death due to heart failure. A consensus is also lacking on the best HR variability measure for clinical purposes. Time and frequency domain measures of HR variability have been most commonly used, but recent studies show that new analysis methods based on nonlinear dynamics may be more powerful in terms of risk stratification. Before the measurement of HR variability can be applied to clinical practice and used to direct therapy, more precise insight into the pathophysiological link between HR variability and mortality are needed. Further studies should also address the issue of which of the HR variability indexes, including the new nonlinear measures, is best for clinical purposes in various patient populations.

Original languageEnglish
Pages (from-to)1878-1883
Number of pages6
JournalJournal of the American College of Cardiology
Volume34
Issue number7
DOIs
StatePublished - Dec 1 1999

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Play and Playthings
Heart Rate
Research
Nonlinear Dynamics
Mortality
Blood Vessels
Coronary Artery Disease
Cause of Death
Heart Diseases
Heart Failure

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Measurement of heart rate variability : A clinical tool or a research toy? / Huikuri, Heikki V.; Mäkikallio, Timo; Airaksinen, K. E Juhani; Mitrani, Raul; Castellanos, Agustin; Myerburg, Robert J.

In: Journal of the American College of Cardiology, Vol. 34, No. 7, 01.12.1999, p. 1878-1883.

Research output: Contribution to journalArticle

Huikuri, Heikki V. ; Mäkikallio, Timo ; Airaksinen, K. E Juhani ; Mitrani, Raul ; Castellanos, Agustin ; Myerburg, Robert J. / Measurement of heart rate variability : A clinical tool or a research toy?. In: Journal of the American College of Cardiology. 1999 ; Vol. 34, No. 7. pp. 1878-1883.
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