Measurement of crystalline lens volume during accommodation in a lens stretcher

Lauren Marussich, Fabrice Manns, Derek Nankivil, Bianca Maceo Heilman, Yue Yao, Esdras Arrieta-Quintero, Arthur Ho, Robert Augusteyn, Jean Marie Parel

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

PURPOSE. To determine if the lens volume changes during accommodation. METHODS. The study used data acquired on 36 cynomolgus monkey lenses that were stretched in a stepwise fashion to simulate disaccommodation. At each step, stretching force and dioptric power were measured and a cross-sectional image of the lens was acquired using an optical coherence tomography system. Images were corrected for refractive distortions and lens volume was calculated assuming rotational symmetry. The average change in lens volume was calculated and the relation between volume change and power change, and between volume change and stretching force, were quantified. Linear regressions of volume-power and volume-force plots were calculated. RESULTS. The mean (±SD) volume in the unstretched (accommodated) state was 97 ± 8 mm3. On average, there was a small but statistically significant (P = 0.002) increase in measured lens volume with stretching. The mean change in lens volume was +0.8 ± 1.3 mm3. The mean volume-power and volume-load slopes were -0.018 ± 0.058 mm3/D and +0.16 ± 0.40 mm3/g. CONCLUSIONS. Lens volume remains effectively constant during accommodation, with changes that are less than 1% on average. This result supports a hypothesis that the change in lens shape with accommodation is accompanied by a redistribution of tissue within the capsular bag without significant compression of the lens contents or fluid exchange through the capsule.

Original languageEnglish (US)
Pages (from-to)4239-4248
Number of pages10
JournalInvestigative Ophthalmology and Visual Science
Volume56
Issue number8
DOIs
StatePublished - 2015

Keywords

  • Accommodation
  • Crystalline lens
  • Optical coherence tomography
  • Volume

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Marussich, L., Manns, F., Nankivil, D., Heilman, B. M., Yao, Y., Arrieta-Quintero, E., Ho, A., Augusteyn, R., & Parel, J. M. (2015). Measurement of crystalline lens volume during accommodation in a lens stretcher. Investigative Ophthalmology and Visual Science, 56(8), 4239-4248. https://doi.org/10.1167/iovs.15-17050