Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock

T. J. Oglesby, D. R. Schultz, R. M.H. Schein, C. L. Sprung, J. E. Volanakis

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalComplement and Inflammation
Volume6
Issue number1
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Immunology
  • Hematology

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