Abstract
We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.
| Original language | English |
|---|---|
| Pages (from-to) | 27-35 |
| Number of pages | 9 |
| Journal | Complement and Inflammation |
| Volume | 6 |
| Issue number | 1 |
| State | Published - Jan 1 1989 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology
- Hematology
Cite this
Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. / Oglesby, T. J.; Schultz, D. R.; Schein, Roland; Sprung, C. L.; Volanakis, J. E.
In: Complement and Inflammation, Vol. 6, No. 1, 01.01.1989, p. 27-35.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock
AU - Oglesby, T. J.
AU - Schultz, D. R.
AU - Schein, Roland
AU - Sprung, C. L.
AU - Volanakis, J. E.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.
AB - We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.
UR - http://www.scopus.com/inward/record.url?scp=0024574826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024574826&partnerID=8YFLogxK
M3 - Article
C2 - 2706954
AN - SCOPUS:0024574826
VL - 6
SP - 27
EP - 35
JO - Complement and Inflammation
JF - Complement and Inflammation
SN - 1012-8204
IS - 1
ER -