Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock

T. J. Oglesby, D. R. Schultz, Roland Schein, C. L. Sprung, J. E. Volanakis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalComplement and Inflammation
Volume6
Issue number1
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Complement C2
Complement Factor B
Septic Shock
Systemic Lupus Erythematosus
Acute-Phase Reaction
Liver Cirrhosis
Infection
Serum

ASJC Scopus subject areas

  • Immunology
  • Hematology

Cite this

Oglesby, T. J., Schultz, D. R., Schein, R., Sprung, C. L., & Volanakis, J. E. (1989). Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. Complement and Inflammation, 6(1), 27-35.

Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. / Oglesby, T. J.; Schultz, D. R.; Schein, Roland; Sprung, C. L.; Volanakis, J. E.

In: Complement and Inflammation, Vol. 6, No. 1, 01.01.1989, p. 27-35.

Research output: Contribution to journalArticle

Oglesby, TJ, Schultz, DR, Schein, R, Sprung, CL & Volanakis, JE 1989, 'Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock', Complement and Inflammation, vol. 6, no. 1, pp. 27-35.
Oglesby, T. J. ; Schultz, D. R. ; Schein, Roland ; Sprung, C. L. ; Volanakis, J. E. / Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. In: Complement and Inflammation. 1989 ; Vol. 6, No. 1. pp. 27-35.
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