Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock

T. J. Oglesby, D. R. Schultz, Roland Schein, C. L. Sprung, J. E. Volanakis

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalComplement and Inflammation
Volume6
Issue number1
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Complement C2
Complement Factor B
Septic Shock
Systemic Lupus Erythematosus
Acute-Phase Reaction
Liver Cirrhosis
Infection
Serum

ASJC Scopus subject areas

  • Immunology
  • Hematology

Cite this

Oglesby, T. J., Schultz, D. R., Schein, R., Sprung, C. L., & Volanakis, J. E. (1989). Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. Complement and Inflammation, 6(1), 27-35.

Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. / Oglesby, T. J.; Schultz, D. R.; Schein, Roland; Sprung, C. L.; Volanakis, J. E.

In: Complement and Inflammation, Vol. 6, No. 1, 01.01.1989, p. 27-35.

Research output: Contribution to journal › Article

Oglesby, TJ, Schultz, DR, Schein, R, Sprung, CL & Volanakis, JE 1989, 'Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock', Complement and Inflammation, vol. 6, no. 1, pp. 27-35.
Oglesby TJ, Schultz DR, Schein R, Sprung CL, Volanakis JE. Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. Complement and Inflammation. 1989 Jan 1;6(1):27-35.
Oglesby, T. J. ; Schultz, D. R. ; Schein, Roland ; Sprung, C. L. ; Volanakis, J. E. / Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. In: Complement and Inflammation. 1989 ; Vol. 6, No. 1. pp. 27-35.
@article{45dcb6b3433442ef9610d93c242e743a,
title = "Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock",
abstract = "We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.",
author = "Oglesby, {T. J.} and Schultz, {D. R.} and Roland Schein and Sprung, {C. L.} and Volanakis, {J. E.}",
year = "1989",
month = "1",
day = "1",
language = "English",
volume = "6",
pages = "27--35",
journal = "Complement and Inflammation",
issn = "1012-8204",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock

AU - Oglesby, T. J.

AU - Schultz, D. R.

AU - Schein, Roland

AU - Sprung, C. L.

AU - Volanakis, J. E.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.

AB - We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.

UR - http://www.scopus.com/inward/record.url?scp=0024574826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024574826&partnerID=8YFLogxK

M3 - Article

VL - 6

SP - 27

EP - 35

JO - Complement and Inflammation

JF - Complement and Inflammation

SN - 1012-8204

IS - 1

ER -

Access to Document