Measles immunization in HIV-infected children

N. A. Halsey, J. S. Abramson, P. J. Chesney, M. C. Fisher, M. A. Gerger, S. M. Marcy, D. L. Murray, G. D. Overturf, C. G. Prober, L. B. Weiner, R. J. Whitley, R. Yogev, C. Wilfert, J. E. Aronson, D. T. Beck, A. R. Fleischman, M. W. Kline, L. M. Mofenson, G. B. Scott, D. W. WaraP. N. Whitley-Williams

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

Children infected with human immunodeficiency virus (HIV) have had high rates of mortality attributable to measles, but until recently, measles vaccine was assumed to be safe for these children. A single fatal case of pneumonia attributable to vaccine type-measles virus has been documented in a young adult with acquired immunodeficiency syndrome. Because a protective immune response often does not develop in severely immunocompromised HIV- infected patients after immunization and some risk of severe complications exists, HIV-infected children, adolescents, and young adults who are severely immunocompromised (based on age-specific CD4 lymphocyte enumeration) attributable to HIV infection should not receive measles vaccine. All other HIV-infected children, adolescents, and young adults who are not severely immunocompromised should received measles-mumps-rubella vaccine.

Original languageEnglish (US)
Pages (from-to)1057-1060
Number of pages4
JournalPediatrics
Volume103
Issue number5 I
DOIs
StatePublished - May 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Halsey, N. A., Abramson, J. S., Chesney, P. J., Fisher, M. C., Gerger, M. A., Marcy, S. M., Murray, D. L., Overturf, G. D., Prober, C. G., Weiner, L. B., Whitley, R. J., Yogev, R., Wilfert, C., Aronson, J. E., Beck, D. T., Fleischman, A. R., Kline, M. W., Mofenson, L. M., Scott, G. B., ... Whitley-Williams, P. N. (1999). Measles immunization in HIV-infected children. Pediatrics, 103(5 I), 1057-1060. https://doi.org/10.1542/peds.103.5.1057