MDS stem cell biology

Sarah M. Greenblatt, H. Joachim Deeg, Stephen D Nimer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The clinical heterogeneity of patients with myelodysplastic syndromes suggests that there must also be a broad range of pathogenetic abnormalities that underlie this disorder. It is clear that the molecular abnormalities associated with MDS are vast, as are the functional abnormalities within the hematopoietic compartment. This implies that there may also be significant differences in the cell of origin and varying degrees of aberrant communication with the microenvironment in individual patients. It is only through recent advances in flow cytometry, DNA sequencing, and high throughput analysis of the genome, proteome, and RNA expression profiles that we can make these general but profound statements about the spectrum of abnormalities in MDS patients.

Original languageEnglish (US)
Title of host publicationMyelodysplastic Syndromes, Second Edition
PublisherSpringer Berlin Heidelberg
Pages73-84
Number of pages12
ISBN (Electronic)9783642362293
ISBN (Print)9783642362286
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Greenblatt, S. M., Deeg, H. J., & Nimer, S. D. (2013). MDS stem cell biology. In Myelodysplastic Syndromes, Second Edition (pp. 73-84). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-36229-3_4