Abstract
We compared three methods of reporting maximal expiratory flow (V′maxFRC) measured in partial expiratory flow-volume curves (PEFVCs) at the point of functional residual capacity (FRC). PEFVCs were obtained with the rapid thoracoabdominal compression technique (RTC) on a total of 446 occasions in 281 HIV-negative, asymptomatic infants (4.8-28.1 months old). Three different expressions of V′maxFRC were recorded: 1) the highest measured flow (maxV′FRC), 2) the mean of the three highest flows (mean3V′FRC), and 3) the flow at FRC in a composite curve (compV′FRC) consisting of PEFVCs, obtained at different jacket pressures and superimposed at their distal limb. The numerical value of maxV′FRC was 7.4% (±5.6%) higher than the mean3V′FRC, and 11.9% (±17.7%) higher than the compV′FRC; the mean3V′FRC was 5% (±18.3%) higher than the compV/FRC. Bland-Altman analysis was used to evaluate the agreement between the three indices. The mean difference and 95% limits of agreement were: maxV′FRC-mean3V′ FRC, 14 ± 18 ml/sec; maxV′FRC - compV′FRC, 23 ± 58 ml/sec; and mean3V′ FRC - compV′FRC, 10 ± 52 ml/sec. The differences between the slopes of the three indices (regressed against height) were statistically significant, although clinically unimportant. We conclude that despite their high correlation, the mean3V′FRC and maxV′FRC should not be used interchangeably, and that the composite analysis, although useful, does not improve the reproducibility of V′maxFRC, and thus it cannot be recommended for routine use in its current form.
| Original language | English |
|---|---|
| Pages (from-to) | 318-323 |
| Number of pages | 6 |
| Journal | Pediatric Pulmonology |
| Volume | 37 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2004 |
| Externally published | Yes |
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Keywords
- Infant pulmonary function testing
- Maximal expiratory flow
- Partial expiratory flow-volume curves
- Rapid thoracoabdominal compression
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pulmonary and Respiratory Medicine
Cite this
Maximal Expiratory Flow at FRC (V′maxFRC) : Methods of Selection and Differences in Reported Values. / Koumbourlis, Anastassios C.; Chen, Xin C.; Rao, Jonnagadda S; Schluchter, Mark D.; Easley, Kirk; Colin, Andrew; Hiatt, Peter; Kattan, Meyer; McCarthy, Kevin; Mellins, Robert B.; Peavy, Hannah; Platzker, Arnold C G; Steinbach, Suzanne; Ting, Andrew; Weisner, Michael D.; Wohl, Mary Ellen B.
In: Pediatric Pulmonology, Vol. 37, No. 4, 01.04.2004, p. 318-323.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Maximal Expiratory Flow at FRC (V′maxFRC)
T2 - Methods of Selection and Differences in Reported Values
AU - Koumbourlis, Anastassios C.
AU - Chen, Xin C.
AU - Rao, Jonnagadda S
AU - Schluchter, Mark D.
AU - Easley, Kirk
AU - Colin, Andrew
AU - Hiatt, Peter
AU - Kattan, Meyer
AU - McCarthy, Kevin
AU - Mellins, Robert B.
AU - Peavy, Hannah
AU - Platzker, Arnold C G
AU - Steinbach, Suzanne
AU - Ting, Andrew
AU - Weisner, Michael D.
AU - Wohl, Mary Ellen B
PY - 2004/4/1
Y1 - 2004/4/1
N2 - We compared three methods of reporting maximal expiratory flow (V′maxFRC) measured in partial expiratory flow-volume curves (PEFVCs) at the point of functional residual capacity (FRC). PEFVCs were obtained with the rapid thoracoabdominal compression technique (RTC) on a total of 446 occasions in 281 HIV-negative, asymptomatic infants (4.8-28.1 months old). Three different expressions of V′maxFRC were recorded: 1) the highest measured flow (maxV′FRC), 2) the mean of the three highest flows (mean3V′FRC), and 3) the flow at FRC in a composite curve (compV′FRC) consisting of PEFVCs, obtained at different jacket pressures and superimposed at their distal limb. The numerical value of maxV′FRC was 7.4% (±5.6%) higher than the mean3V′FRC, and 11.9% (±17.7%) higher than the compV′FRC; the mean3V′FRC was 5% (±18.3%) higher than the compV/FRC. Bland-Altman analysis was used to evaluate the agreement between the three indices. The mean difference and 95% limits of agreement were: maxV′FRC-mean3V′ FRC, 14 ± 18 ml/sec; maxV′FRC - compV′FRC, 23 ± 58 ml/sec; and mean3V′ FRC - compV′FRC, 10 ± 52 ml/sec. The differences between the slopes of the three indices (regressed against height) were statistically significant, although clinically unimportant. We conclude that despite their high correlation, the mean3V′FRC and maxV′FRC should not be used interchangeably, and that the composite analysis, although useful, does not improve the reproducibility of V′maxFRC, and thus it cannot be recommended for routine use in its current form.
AB - We compared three methods of reporting maximal expiratory flow (V′maxFRC) measured in partial expiratory flow-volume curves (PEFVCs) at the point of functional residual capacity (FRC). PEFVCs were obtained with the rapid thoracoabdominal compression technique (RTC) on a total of 446 occasions in 281 HIV-negative, asymptomatic infants (4.8-28.1 months old). Three different expressions of V′maxFRC were recorded: 1) the highest measured flow (maxV′FRC), 2) the mean of the three highest flows (mean3V′FRC), and 3) the flow at FRC in a composite curve (compV′FRC) consisting of PEFVCs, obtained at different jacket pressures and superimposed at their distal limb. The numerical value of maxV′FRC was 7.4% (±5.6%) higher than the mean3V′FRC, and 11.9% (±17.7%) higher than the compV′FRC; the mean3V′FRC was 5% (±18.3%) higher than the compV/FRC. Bland-Altman analysis was used to evaluate the agreement between the three indices. The mean difference and 95% limits of agreement were: maxV′FRC-mean3V′ FRC, 14 ± 18 ml/sec; maxV′FRC - compV′FRC, 23 ± 58 ml/sec; and mean3V′ FRC - compV′FRC, 10 ± 52 ml/sec. The differences between the slopes of the three indices (regressed against height) were statistically significant, although clinically unimportant. We conclude that despite their high correlation, the mean3V′FRC and maxV′FRC should not be used interchangeably, and that the composite analysis, although useful, does not improve the reproducibility of V′maxFRC, and thus it cannot be recommended for routine use in its current form.
KW - Infant pulmonary function testing
KW - Maximal expiratory flow
KW - Partial expiratory flow-volume curves
KW - Rapid thoracoabdominal compression
UR - http://www.scopus.com/inward/record.url?scp=11144355871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144355871&partnerID=8YFLogxK
U2 - 10.1002/ppul.10452
DO - 10.1002/ppul.10452
M3 - Article
C2 - 15022128
AN - SCOPUS:11144355871
VL - 37
SP - 318
EP - 323
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
SN - 8755-6863
IS - 4
ER -