Maximal Expiratory Flow at FRC (V′maxFRC): Methods of Selection and Differences in Reported Values

Anastassios C. Koumbourlis, Xin C. Chen, Jonnagadda S Rao, Mark D. Schluchter, Kirk Easley, Andrew Colin, Peter Hiatt, Meyer Kattan, Kevin McCarthy, Robert B. Mellins, Hannah Peavy, Arnold C G Platzker, Suzanne Steinbach, Andrew Ting, Michael D. Weisner, Mary Ellen B Wohl

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We compared three methods of reporting maximal expiratory flow (V′maxFRC) measured in partial expiratory flow-volume curves (PEFVCs) at the point of functional residual capacity (FRC). PEFVCs were obtained with the rapid thoracoabdominal compression technique (RTC) on a total of 446 occasions in 281 HIV-negative, asymptomatic infants (4.8-28.1 months old). Three different expressions of V′maxFRC were recorded: 1) the highest measured flow (maxV′FRC), 2) the mean of the three highest flows (mean3V′FRC), and 3) the flow at FRC in a composite curve (compV′FRC) consisting of PEFVCs, obtained at different jacket pressures and superimposed at their distal limb. The numerical value of maxV′FRC was 7.4% (±5.6%) higher than the mean3V′FRC, and 11.9% (±17.7%) higher than the compV′FRC; the mean3V′FRC was 5% (±18.3%) higher than the compV/FRC. Bland-Altman analysis was used to evaluate the agreement between the three indices. The mean difference and 95% limits of agreement were: maxV′FRC-mean3V′ FRC, 14 ± 18 ml/sec; maxV′FRC - compV′FRC, 23 ± 58 ml/sec; and mean3V′ FRC - compV′FRC, 10 ± 52 ml/sec. The differences between the slopes of the three indices (regressed against height) were statistically significant, although clinically unimportant. We conclude that despite their high correlation, the mean3V′FRC and maxV′FRC should not be used interchangeably, and that the composite analysis, although useful, does not improve the reproducibility of V′maxFRC, and thus it cannot be recommended for routine use in its current form.

Original languageEnglish
Pages (from-to)318-323
Number of pages6
JournalPediatric Pulmonology
Volume37
Issue number4
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

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Functional Residual Capacity
Extremities
HIV
Pressure

Keywords

  • Infant pulmonary function testing
  • Maximal expiratory flow
  • Partial expiratory flow-volume curves
  • Rapid thoracoabdominal compression

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Koumbourlis, A. C., Chen, X. C., Rao, J. S., Schluchter, M. D., Easley, K., Colin, A., ... Wohl, M. E. B. (2004). Maximal Expiratory Flow at FRC (V′maxFRC): Methods of Selection and Differences in Reported Values. Pediatric Pulmonology, 37(4), 318-323. https://doi.org/10.1002/ppul.10452

Maximal Expiratory Flow at FRC (V′maxFRC) : Methods of Selection and Differences in Reported Values. / Koumbourlis, Anastassios C.; Chen, Xin C.; Rao, Jonnagadda S; Schluchter, Mark D.; Easley, Kirk; Colin, Andrew; Hiatt, Peter; Kattan, Meyer; McCarthy, Kevin; Mellins, Robert B.; Peavy, Hannah; Platzker, Arnold C G; Steinbach, Suzanne; Ting, Andrew; Weisner, Michael D.; Wohl, Mary Ellen B.

In: Pediatric Pulmonology, Vol. 37, No. 4, 01.04.2004, p. 318-323.

Research output: Contribution to journalArticle

Koumbourlis, AC, Chen, XC, Rao, JS, Schluchter, MD, Easley, K, Colin, A, Hiatt, P, Kattan, M, McCarthy, K, Mellins, RB, Peavy, H, Platzker, ACG, Steinbach, S, Ting, A, Weisner, MD & Wohl, MEB 2004, 'Maximal Expiratory Flow at FRC (V′maxFRC): Methods of Selection and Differences in Reported Values', Pediatric Pulmonology, vol. 37, no. 4, pp. 318-323. https://doi.org/10.1002/ppul.10452
Koumbourlis, Anastassios C. ; Chen, Xin C. ; Rao, Jonnagadda S ; Schluchter, Mark D. ; Easley, Kirk ; Colin, Andrew ; Hiatt, Peter ; Kattan, Meyer ; McCarthy, Kevin ; Mellins, Robert B. ; Peavy, Hannah ; Platzker, Arnold C G ; Steinbach, Suzanne ; Ting, Andrew ; Weisner, Michael D. ; Wohl, Mary Ellen B. / Maximal Expiratory Flow at FRC (V′maxFRC) : Methods of Selection and Differences in Reported Values. In: Pediatric Pulmonology. 2004 ; Vol. 37, No. 4. pp. 318-323.
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AU - Schluchter, Mark D.

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AU - Kattan, Meyer

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