Abstract
The movement of cells and the accompanied remodeling of the extracellular matrix is a critical step in many developmental processes. The matrix metalloproteinases (MMPs) are well recognized as mediators of matrix degradation, and their activity as regulators of signaling pathways by virtue of the cleavage of nonmatrix substrates has been increasingly appreciated. In this review, we focus on the role of MMPs in altering processes that influence cellular motility. MMP involvement in cellular adhesion, lamellipodia-directed movement, invadopodial protrusion, axonal growth cone extension, and chemotaxis are discussed. Although not designed to be comprehensive, these examples clearly demonstrate that cellular regulation of the MMPs influences cell motility in a variety of ways, including regulating cell-cell interactions, cell-matrix interactions, matrix degradation, and the release of bioactive signaling molecules. Deregulation of these interactions can ultimately result in disorders including inflammatory diseases, vascular diseases, bone diseases, neurological disorders, and cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 69-79 |
| Number of pages | 11 |
| Journal | Birth Defects Research Part C - Embryo Today: Reviews |
| Volume | 78 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Embryology
Cite this
Matrix metalloproteinases and cellular motility in development and disease. / Vansaun, Michael; Matrisian, Lynn M.
In: Birth Defects Research Part C - Embryo Today: Reviews, Vol. 78, No. 1, 03.2006, p. 69-79.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Matrix metalloproteinases and cellular motility in development and disease
AU - Vansaun, Michael
AU - Matrisian, Lynn M.
PY - 2006/3
Y1 - 2006/3
N2 - The movement of cells and the accompanied remodeling of the extracellular matrix is a critical step in many developmental processes. The matrix metalloproteinases (MMPs) are well recognized as mediators of matrix degradation, and their activity as regulators of signaling pathways by virtue of the cleavage of nonmatrix substrates has been increasingly appreciated. In this review, we focus on the role of MMPs in altering processes that influence cellular motility. MMP involvement in cellular adhesion, lamellipodia-directed movement, invadopodial protrusion, axonal growth cone extension, and chemotaxis are discussed. Although not designed to be comprehensive, these examples clearly demonstrate that cellular regulation of the MMPs influences cell motility in a variety of ways, including regulating cell-cell interactions, cell-matrix interactions, matrix degradation, and the release of bioactive signaling molecules. Deregulation of these interactions can ultimately result in disorders including inflammatory diseases, vascular diseases, bone diseases, neurological disorders, and cancer.
AB - The movement of cells and the accompanied remodeling of the extracellular matrix is a critical step in many developmental processes. The matrix metalloproteinases (MMPs) are well recognized as mediators of matrix degradation, and their activity as regulators of signaling pathways by virtue of the cleavage of nonmatrix substrates has been increasingly appreciated. In this review, we focus on the role of MMPs in altering processes that influence cellular motility. MMP involvement in cellular adhesion, lamellipodia-directed movement, invadopodial protrusion, axonal growth cone extension, and chemotaxis are discussed. Although not designed to be comprehensive, these examples clearly demonstrate that cellular regulation of the MMPs influences cell motility in a variety of ways, including regulating cell-cell interactions, cell-matrix interactions, matrix degradation, and the release of bioactive signaling molecules. Deregulation of these interactions can ultimately result in disorders including inflammatory diseases, vascular diseases, bone diseases, neurological disorders, and cancer.
UR - http://www.scopus.com/inward/record.url?scp=33646537449&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646537449&partnerID=8YFLogxK
U2 - 10.1002/bdrc.20061
DO - 10.1002/bdrc.20061
M3 - Article
C2 - 16622849
AN - SCOPUS:33646537449
VL - 78
SP - 69
EP - 79
JO - Birth Defects Research Part C - Embryo Today: Reviews
JF - Birth Defects Research Part C - Embryo Today: Reviews
SN - 1542-975X
IS - 1
ER -