Matrix Effects

Jeffrey A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The extracellular matrix is a complex chemically and physically crosslinked network of proteins and glycosaminoglycans. This matrix serves to organize cells in space, to provide them with environmental signals to direct site-specific cellular regulation and to separate one tissue space from another. The interaction between cells and the extracellular matrix is bi-directional and dynamic: cells are constantly accepting information about their environment from cues in the extracellular matrix, and cells are frequently remodeling their extracellular matrix. In this chapter, the proteins in the extracellular matrix and their cell-surface receptors are introduced, and mechanisms by which cells transduce chemical information in their extracellular matrix are discussed. The complex interplay between signaling from matrix molecules and associated growth factors is presented. Methods for spatially displaying matrix recognition factors on and in biomaterials is described, both in the context of model systems for investigation of cellular behavior and from the perspective of creation of bioactive biomaterials for tissue-engineering therapies.

Original languageEnglish (US)
Title of host publicationPrinciples of Tissue Engineering
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Pages407-421
Number of pages15
ISBN (Print)9780123983589
DOIs
StatePublished - Nov 1 2013

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Keywords

  • Adhesion
  • Cadherin
  • Cell adhesion molecule
  • Collagen
  • Fibronectin
  • Growth factor
  • Integrin
  • Laminin
  • Matrix
  • Migration
  • Selectin
  • Vitronectin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hubbell, J. A. (2013). Matrix Effects. In Principles of Tissue Engineering: Fourth Edition (pp. 407-421). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398358-9.00021-5