Abstract
The matrix-bound growth factor-based therapies for soft tissue healing are analyzed. Growth factor variants are designed as fusion proteins of a fibrin-binding immobilization site, a proteolytic cleavage site, and the growth factor. The function of angiogenic growth factors are also addressed, as chronic dermal wound is related to an angiogenic deficit in the skin. A fibrin-binding fusion with the avb3-ligand found in the sixth Ig-like domain of L1 (L1Ig6) was formed, and this domain induced endothelial process extension in vitro and angiogenesis in vivo similarly to bound vascular endothelial growth factor (VEGF).
| Original language | English |
|---|---|
| Title of host publication | Transactions - 7th World Biomaterials Congress |
| State | Published - Dec 1 2004 |
| Externally published | Yes |
| Event | Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: May 17 2004 → May 21 2004 |
Other
| Other | Transactions - 7th World Biomaterials Congress |
|---|---|
| Country | Australia |
| City | Sydney |
| Period | 5/17/04 → 5/21/04 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Matrix-bound growth factors in soft tissue healing. / Hubbell, J. A.; Hall, H.; Trentin, D.; Weschler, S.; Zisch, A. H.
Transactions - 7th World Biomaterials Congress. 2004.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Matrix-bound growth factors in soft tissue healing
AU - Hubbell, J. A.
AU - Hall, H.
AU - Trentin, D.
AU - Weschler, S.
AU - Zisch, A. H.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - The matrix-bound growth factor-based therapies for soft tissue healing are analyzed. Growth factor variants are designed as fusion proteins of a fibrin-binding immobilization site, a proteolytic cleavage site, and the growth factor. The function of angiogenic growth factors are also addressed, as chronic dermal wound is related to an angiogenic deficit in the skin. A fibrin-binding fusion with the avb3-ligand found in the sixth Ig-like domain of L1 (L1Ig6) was formed, and this domain induced endothelial process extension in vitro and angiogenesis in vivo similarly to bound vascular endothelial growth factor (VEGF).
AB - The matrix-bound growth factor-based therapies for soft tissue healing are analyzed. Growth factor variants are designed as fusion proteins of a fibrin-binding immobilization site, a proteolytic cleavage site, and the growth factor. The function of angiogenic growth factors are also addressed, as chronic dermal wound is related to an angiogenic deficit in the skin. A fibrin-binding fusion with the avb3-ligand found in the sixth Ig-like domain of L1 (L1Ig6) was formed, and this domain induced endothelial process extension in vitro and angiogenesis in vivo similarly to bound vascular endothelial growth factor (VEGF).
UR - http://www.scopus.com/inward/record.url?scp=13844276213&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13844276213&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:13844276213
SN - 1877040193
SN - 9781877040191
BT - Transactions - 7th World Biomaterials Congress
ER -