Matrix-bound growth factors in soft tissue healing

J. A. Hubbell, H. Hall, D. Trentin, S. Weschler, A. H. Zisch

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The matrix-bound growth factor-based therapies for soft tissue healing are analyzed. Growth factor variants are designed as fusion proteins of a fibrin-binding immobilization site, a proteolytic cleavage site, and the growth factor. The function of angiogenic growth factors are also addressed, as chronic dermal wound is related to an angiogenic deficit in the skin. A fibrin-binding fusion with the avb3-ligand found in the sixth Ig-like domain of L1 (L1Ig6) was formed, and this domain induced endothelial process extension in vitro and angiogenesis in vivo similarly to bound vascular endothelial growth factor (VEGF).

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Hubbell, J. A., Hall, H., Trentin, D., Weschler, S., & Zisch, A. H. (2004). Matrix-bound growth factors in soft tissue healing. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).