Abstract
The matrix-bound growth factor-based therapies for soft tissue healing are analyzed. Growth factor variants are designed as fusion proteins of a fibrin-binding immobilization site, a proteolytic cleavage site, and the growth factor. The function of angiogenic growth factors are also addressed, as chronic dermal wound is related to an angiogenic deficit in the skin. A fibrin-binding fusion with the avb3-ligand found in the sixth Ig-like domain of L1 (L1Ig6) was formed, and this domain induced endothelial process extension in vitro and angiogenesis in vivo similarly to bound vascular endothelial growth factor (VEGF).
| Original language | English (US) |
|---|---|
| Title of host publication | Transactions - 7th World Biomaterials Congress |
| Number of pages | 1 |
| State | Published - Dec 1 2004 |
| Event | Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: May 17 2004 → May 21 2004 |
Publication series
| Name | Transactions - 7th World Biomaterials Congress |
|---|
Other
| Other | Transactions - 7th World Biomaterials Congress |
|---|---|
| Country | Australia |
| City | Sydney |
| Period | 5/17/04 → 5/21/04 |
ASJC Scopus subject areas
- Engineering(all)
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Cite this
Hubbell, J. A., Hall, H., Trentin, D., Weschler, S., & Zisch, A. H. (2004). Matrix-bound growth factors in soft tissue healing. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).