TY - GEN
T1 - Matrix-bound growth factors in soft tissue healing
AU - Hubbell, J. A.
AU - Hall, H.
AU - Trentin, D.
AU - Weschler, S.
AU - Zisch, A. H.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - The matrix-bound growth factor-based therapies for soft tissue healing are analyzed. Growth factor variants are designed as fusion proteins of a fibrin-binding immobilization site, a proteolytic cleavage site, and the growth factor. The function of angiogenic growth factors are also addressed, as chronic dermal wound is related to an angiogenic deficit in the skin. A fibrin-binding fusion with the avb3-ligand found in the sixth Ig-like domain of L1 (L1Ig6) was formed, and this domain induced endothelial process extension in vitro and angiogenesis in vivo similarly to bound vascular endothelial growth factor (VEGF).
AB - The matrix-bound growth factor-based therapies for soft tissue healing are analyzed. Growth factor variants are designed as fusion proteins of a fibrin-binding immobilization site, a proteolytic cleavage site, and the growth factor. The function of angiogenic growth factors are also addressed, as chronic dermal wound is related to an angiogenic deficit in the skin. A fibrin-binding fusion with the avb3-ligand found in the sixth Ig-like domain of L1 (L1Ig6) was formed, and this domain induced endothelial process extension in vitro and angiogenesis in vivo similarly to bound vascular endothelial growth factor (VEGF).
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M3 - Conference contribution
AN - SCOPUS:13844276213
SN - 1877040193
SN - 9781877040191
T3 - Transactions - 7th World Biomaterials Congress
BT - Transactions - 7th World Biomaterials Congress
T2 - Transactions - 7th World Biomaterials Congress
Y2 - 17 May 2004 through 21 May 2004
ER -