Matrix-bound growth factors in soft tissue healing

J. A. Hubbell; H. Hall; D. Trentin; S. Weschler; A. H. Zisch

Matrix-bound growth factors in soft tissue healing

J. A. Hubbell, H. Hall, D. Trentin, S. Weschler, A. H. Zisch

Surgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The matrix-bound growth factor-based therapies for soft tissue healing are analyzed. Growth factor variants are designed as fusion proteins of a fibrin-binding immobilization site, a proteolytic cleavage site, and the growth factor. The function of angiogenic growth factors are also addressed, as chronic dermal wound is related to an angiogenic deficit in the skin. A fibrin-binding fusion with the avb3-ligand found in the sixth Ig-like domain of L1 (L1Ig6) was formed, and this domain induced endothelial process extension in vitro and angiogenesis in vivo similarly to bound vascular endothelial growth factor (VEGF).

Original language	English (US)
Title of host publication	Transactions - 7th World Biomaterials Congress
Number of pages	1
State	Published - Dec 1 2004
Event	Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: May 17 2004 → May 21 2004

Publication series

Name	Transactions - 7th World Biomaterials Congress

Other

Other	Transactions - 7th World Biomaterials Congress
Country	Australia
City	Sydney
Period	5/17/04 → 5/21/04

ASJC Scopus subject areas

Engineering(all)

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Cite this

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title = "Matrix-bound growth factors in soft tissue healing",

abstract = "The matrix-bound growth factor-based therapies for soft tissue healing are analyzed. Growth factor variants are designed as fusion proteins of a fibrin-binding immobilization site, a proteolytic cleavage site, and the growth factor. The function of angiogenic growth factors are also addressed, as chronic dermal wound is related to an angiogenic deficit in the skin. A fibrin-binding fusion with the avb3-ligand found in the sixth Ig-like domain of L1 (L1Ig6) was formed, and this domain induced endothelial process extension in vitro and angiogenesis in vivo similarly to bound vascular endothelial growth factor (VEGF).",

author = "Hubbell, {J. A.} and H. Hall and D. Trentin and S. Weschler and Zisch, {A. H.}",

year = "2004",

month = dec,

day = "1",

language = "English (US)",

isbn = "1877040193",

series = "Transactions - 7th World Biomaterials Congress",

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note = "Transactions - 7th World Biomaterials Congress ; Conference date: 17-05-2004 Through 21-05-2004",

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TY - GEN

T1 - Matrix-bound growth factors in soft tissue healing

AU - Hubbell, J. A.

AU - Hall, H.

AU - Trentin, D.

AU - Weschler, S.

AU - Zisch, A. H.

PY - 2004/12/1

Y1 - 2004/12/1

N2 - The matrix-bound growth factor-based therapies for soft tissue healing are analyzed. Growth factor variants are designed as fusion proteins of a fibrin-binding immobilization site, a proteolytic cleavage site, and the growth factor. The function of angiogenic growth factors are also addressed, as chronic dermal wound is related to an angiogenic deficit in the skin. A fibrin-binding fusion with the avb3-ligand found in the sixth Ig-like domain of L1 (L1Ig6) was formed, and this domain induced endothelial process extension in vitro and angiogenesis in vivo similarly to bound vascular endothelial growth factor (VEGF).

AB - The matrix-bound growth factor-based therapies for soft tissue healing are analyzed. Growth factor variants are designed as fusion proteins of a fibrin-binding immobilization site, a proteolytic cleavage site, and the growth factor. The function of angiogenic growth factors are also addressed, as chronic dermal wound is related to an angiogenic deficit in the skin. A fibrin-binding fusion with the avb3-ligand found in the sixth Ig-like domain of L1 (L1Ig6) was formed, and this domain induced endothelial process extension in vitro and angiogenesis in vivo similarly to bound vascular endothelial growth factor (VEGF).

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M3 - Conference contribution

AN - SCOPUS:13844276213

SN - 1877040193

SN - 9781877040191

T3 - Transactions - 7th World Biomaterials Congress

BT - Transactions - 7th World Biomaterials Congress

T2 - Transactions - 7th World Biomaterials Congress

Y2 - 17 May 2004 through 21 May 2004

ER -