Mathematical Modeling of Capillary Electrophoresis in Rectangular Channels

Victor P. Andreev, Sergey G. Dubrovsky, Yuri V. Stepanov

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Electroosmotic flow in rectangular channels with nonequal zeta potentials of the walls was studied. It was shown that in such channels the electroosmotic flow velocity profile may deviate substantially from the usual plug flow profile. This nonuniformity of electroosmotic flow leads to the Taylor dispersion and decreases in the efficiency and resolution of capillary electrophoresis in rectangular channels. Even the 10% difference in the values of the zeta potentials of the opposite walls of the channel leads to the loss of resolution. Thus these effects must be carefully taken into consideration when capillary zone electrophoresis (CZE) is realized in the rectangular channels, especially in the case of micro-CZE.

Original languageEnglish (US)
Pages (from-to)443-450
Number of pages8
JournalJournal of Microcolumn Separations
Issue number6
StatePublished - Jan 1 1997


  • Capillary electrophoresis
  • Efficiency
  • Electroosmotic flow
  • Mathematical modeling
  • Rectangular channels
  • Resolution

ASJC Scopus subject areas

  • Filtration and Separation
  • Mechanical Engineering


Dive into the research topics of 'Mathematical Modeling of Capillary Electrophoresis in Rectangular Channels'. Together they form a unique fingerprint.

Cite this