Abstract
Electroosmotic flow in rectangular channels with nonequal zeta potentials of the walls was studied. It was shown that in such channels the electroosmotic flow velocity profile may deviate substantially from the usual plug flow profile. This nonuniformity of electroosmotic flow leads to the Taylor dispersion and decreases in the efficiency and resolution of capillary electrophoresis in rectangular channels. Even the 10% difference in the values of the zeta potentials of the opposite walls of the channel leads to the loss of resolution. Thus these effects must be carefully taken into consideration when capillary zone electrophoresis (CZE) is realized in the rectangular channels, especially in the case of micro-CZE.
| Original language | English |
|---|---|
| Pages (from-to) | 443-450 |
| Number of pages | 8 |
| Journal | Journal of Microcolumn Separations |
| Volume | 9 |
| Issue number | 6 |
| State | Published - Dec 1 1997 |
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Keywords
- Capillary electrophoresis
- Efficiency
- Electroosmotic flow
- Mathematical modeling
- Rectangular channels
- Resolution
ASJC Scopus subject areas
- Filtration and Separation
- Mechanical Engineering
Cite this
Mathematical Modeling of Capillary Electrophoresis in Rectangular Channels. / Andreev, Victor P.; Dubrovsky, Sergey G.; Stepanov, Yuri V.
In: Journal of Microcolumn Separations, Vol. 9, No. 6, 01.12.1997, p. 443-450.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mathematical Modeling of Capillary Electrophoresis in Rectangular Channels
AU - Andreev, Victor P.
AU - Dubrovsky, Sergey G.
AU - Stepanov, Yuri V.
PY - 1997/12/1
Y1 - 1997/12/1
N2 - Electroosmotic flow in rectangular channels with nonequal zeta potentials of the walls was studied. It was shown that in such channels the electroosmotic flow velocity profile may deviate substantially from the usual plug flow profile. This nonuniformity of electroosmotic flow leads to the Taylor dispersion and decreases in the efficiency and resolution of capillary electrophoresis in rectangular channels. Even the 10% difference in the values of the zeta potentials of the opposite walls of the channel leads to the loss of resolution. Thus these effects must be carefully taken into consideration when capillary zone electrophoresis (CZE) is realized in the rectangular channels, especially in the case of micro-CZE.
AB - Electroosmotic flow in rectangular channels with nonequal zeta potentials of the walls was studied. It was shown that in such channels the electroosmotic flow velocity profile may deviate substantially from the usual plug flow profile. This nonuniformity of electroosmotic flow leads to the Taylor dispersion and decreases in the efficiency and resolution of capillary electrophoresis in rectangular channels. Even the 10% difference in the values of the zeta potentials of the opposite walls of the channel leads to the loss of resolution. Thus these effects must be carefully taken into consideration when capillary zone electrophoresis (CZE) is realized in the rectangular channels, especially in the case of micro-CZE.
KW - Capillary electrophoresis
KW - Efficiency
KW - Electroosmotic flow
KW - Mathematical modeling
KW - Rectangular channels
KW - Resolution
UR - http://www.scopus.com/inward/record.url?scp=0002441714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0002441714&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0002441714
VL - 9
SP - 443
EP - 450
JO - Journal of Microcolumn Separations
JF - Journal of Microcolumn Separations
SN - 1040-7685
IS - 6
ER -