Abstract
Purpose: Laser interstitial thermotherapy is a promising minimally-invasive technique for the treatment of small cancers of the breast that are currently removed surgically by lumpectomy. The purpose of this work was to analyze in-situ temperature fields recorded with stainless-steel thermocouple probes during experimental laser interstitial thermo-therapy (LITT). Methods: Both a CW Nd:YAG laser system emitting 20 W for 25 to 30s and a 980 nm diode laser emitting 10 to 20 W for up to 1200s delivered through a fiber-optic probe were used to create localized heating in fatty cadaver pig tissue and milk as phantoms. To quantify an artifact due to direct heating of the thermocouple probes by laser radiation, experiments were also performed in air, water and intralipid solution. The temperature field around the fiber-optic probe during laser irradiation was measured every 0.3 s or 1 s with an array of up to fifteen needle thermocouple probes. The effect of light absorption by the thermocouples probes was quantified and the time-dependence of the temperature distribution was analyzed. Results: After removal of the thermocouple artifact, the temperature was found to vary exponentially with time with a time constant of 600 to 700 s. Conclusions: The time-dependence of the interstitial temperature can be modeled by exponential functions both during ex vivo and in vivo experiments.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Publisher | Society of Photo-Optical Instrumentation Engineers |
| Pages | 448-454 |
| Number of pages | 7 |
| Volume | 3590 |
| State | Published - 1999 |
| Event | Proceedings of the 1999 Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX - San Jose, CA, USA Duration: Jan 23 1999 → Jan 24 1999 |
Other
| Other | Proceedings of the 1999 Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX |
|---|---|
| City | San Jose, CA, USA |
| Period | 1/23/99 → 1/24/99 |
Fingerprint
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics
Cite this
Mathematical analysis of the temperature field during ex vivo and in vivo experimental laser interstitial thermotherapy (LITT) in breast tissue models. / Manns, Fabrice; Milne, Peter J.; Salas, Nelson; Pandya, Nish; Denham, David B.; Parel, Jean-Marie A; Robinson, David S.
Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3590 Society of Photo-Optical Instrumentation Engineers, 1999. p. 448-454.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Mathematical analysis of the temperature field during ex vivo and in vivo experimental laser interstitial thermotherapy (LITT) in breast tissue models
AU - Manns, Fabrice
AU - Milne, Peter J.
AU - Salas, Nelson
AU - Pandya, Nish
AU - Denham, David B.
AU - Parel, Jean-Marie A
AU - Robinson, David S.
PY - 1999
Y1 - 1999
N2 - Purpose: Laser interstitial thermotherapy is a promising minimally-invasive technique for the treatment of small cancers of the breast that are currently removed surgically by lumpectomy. The purpose of this work was to analyze in-situ temperature fields recorded with stainless-steel thermocouple probes during experimental laser interstitial thermo-therapy (LITT). Methods: Both a CW Nd:YAG laser system emitting 20 W for 25 to 30s and a 980 nm diode laser emitting 10 to 20 W for up to 1200s delivered through a fiber-optic probe were used to create localized heating in fatty cadaver pig tissue and milk as phantoms. To quantify an artifact due to direct heating of the thermocouple probes by laser radiation, experiments were also performed in air, water and intralipid solution. The temperature field around the fiber-optic probe during laser irradiation was measured every 0.3 s or 1 s with an array of up to fifteen needle thermocouple probes. The effect of light absorption by the thermocouples probes was quantified and the time-dependence of the temperature distribution was analyzed. Results: After removal of the thermocouple artifact, the temperature was found to vary exponentially with time with a time constant of 600 to 700 s. Conclusions: The time-dependence of the interstitial temperature can be modeled by exponential functions both during ex vivo and in vivo experiments.
AB - Purpose: Laser interstitial thermotherapy is a promising minimally-invasive technique for the treatment of small cancers of the breast that are currently removed surgically by lumpectomy. The purpose of this work was to analyze in-situ temperature fields recorded with stainless-steel thermocouple probes during experimental laser interstitial thermo-therapy (LITT). Methods: Both a CW Nd:YAG laser system emitting 20 W for 25 to 30s and a 980 nm diode laser emitting 10 to 20 W for up to 1200s delivered through a fiber-optic probe were used to create localized heating in fatty cadaver pig tissue and milk as phantoms. To quantify an artifact due to direct heating of the thermocouple probes by laser radiation, experiments were also performed in air, water and intralipid solution. The temperature field around the fiber-optic probe during laser irradiation was measured every 0.3 s or 1 s with an array of up to fifteen needle thermocouple probes. The effect of light absorption by the thermocouples probes was quantified and the time-dependence of the temperature distribution was analyzed. Results: After removal of the thermocouple artifact, the temperature was found to vary exponentially with time with a time constant of 600 to 700 s. Conclusions: The time-dependence of the interstitial temperature can be modeled by exponential functions both during ex vivo and in vivo experiments.
UR - http://www.scopus.com/inward/record.url?scp=0032683711&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032683711&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:0032683711
VL - 3590
SP - 448
EP - 454
BT - Proceedings of SPIE - The International Society for Optical Engineering
PB - Society of Photo-Optical Instrumentation Engineers
ER -