Mathematical analysis of the temperature field during ex vivo and in vivo experimental laser interstitial thermotherapy (LITT) in breast tissue models

Fabrice Manns; Peter J. Milne; Nelson Salas; Nish Pandya; David B. Denham; Jean Marie Parel; David S. Robinson

Mathematical analysis of the temperature field during ex vivo and in vivo experimental laser interstitial thermotherapy (LITT) in breast tissue models

Fabrice Manns, Peter J. Milne, Nelson Salas, Nish Pandya, David B. Denham, Jean Marie Parel, David S. Robinson

Research output: Contribution to journal › Conference article › peer-review

Abstract

Purpose: Laser interstitial thermotherapy is a promising minimally-invasive technique for the treatment of small cancers of the breast that are currently removed surgically by lumpectomy. The purpose of this work was to analyze in-situ temperature fields recorded with stainless-steel thermocouple probes during experimental laser interstitial thermo-therapy (LITT). Methods: Both a CW Nd:YAG laser system emitting 20 W for 25 to 30s and a 980 nm diode laser emitting 10 to 20 W for up to 1200s delivered through a fiber-optic probe were used to create localized heating in fatty cadaver pig tissue and milk as phantoms. To quantify an artifact due to direct heating of the thermocouple probes by laser radiation, experiments were also performed in air, water and intralipid solution. The temperature field around the fiber-optic probe during laser irradiation was measured every 0.3 s or 1 s with an array of up to fifteen needle thermocouple probes. The effect of light absorption by the thermocouples probes was quantified and the time-dependence of the temperature distribution was analyzed. Results: After removal of the thermocouple artifact, the temperature was found to vary exponentially with time with a time constant of 600 to 700 s. Conclusions: The time-dependence of the interstitial temperature can be modeled by exponential functions both during ex vivo and in vivo experiments.

Original language	English (US)
Pages (from-to)	448-454
Number of pages	7
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	3590
State	Published - Jan 1 1999
Event	Proceedings of the 1999 Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX - San Jose, CA, USA Duration: Jan 23 1999 → Jan 24 1999

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Mathematical analysis of the temperature field during ex vivo and in vivo experimental laser interstitial thermotherapy (LITT) in breast tissue models. / Manns, Fabrice; Milne, Peter J.; Salas, Nelson; Pandya, Nish; Denham, David B.; Parel, Jean Marie; Robinson, David S.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 3590, 01.01.1999, p. 448-454.

Research output: Contribution to journal › Conference article › peer-review

Manns, Fabrice ; Milne, Peter J. ; Salas, Nelson ; Pandya, Nish ; Denham, David B. ; Parel, Jean Marie ; Robinson, David S. / Mathematical analysis of the temperature field during ex vivo and in vivo experimental laser interstitial thermotherapy (LITT) in breast tissue models. In: Proceedings of SPIE - The International Society for Optical Engineering. 1999 ; Vol. 3590. pp. 448-454.

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title = "Mathematical analysis of the temperature field during ex vivo and in vivo experimental laser interstitial thermotherapy (LITT) in breast tissue models",

abstract = "Purpose: Laser interstitial thermotherapy is a promising minimally-invasive technique for the treatment of small cancers of the breast that are currently removed surgically by lumpectomy. The purpose of this work was to analyze in-situ temperature fields recorded with stainless-steel thermocouple probes during experimental laser interstitial thermo-therapy (LITT). Methods: Both a CW Nd:YAG laser system emitting 20 W for 25 to 30s and a 980 nm diode laser emitting 10 to 20 W for up to 1200s delivered through a fiber-optic probe were used to create localized heating in fatty cadaver pig tissue and milk as phantoms. To quantify an artifact due to direct heating of the thermocouple probes by laser radiation, experiments were also performed in air, water and intralipid solution. The temperature field around the fiber-optic probe during laser irradiation was measured every 0.3 s or 1 s with an array of up to fifteen needle thermocouple probes. The effect of light absorption by the thermocouples probes was quantified and the time-dependence of the temperature distribution was analyzed. Results: After removal of the thermocouple artifact, the temperature was found to vary exponentially with time with a time constant of 600 to 700 s. Conclusions: The time-dependence of the interstitial temperature can be modeled by exponential functions both during ex vivo and in vivo experiments.",

author = "Fabrice Manns and Milne, {Peter J.} and Nelson Salas and Nish Pandya and Denham, {David B.} and Parel, {Jean Marie} and Robinson, {David S.}",

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AU - Manns, Fabrice

AU - Milne, Peter J.

AU - Salas, Nelson

AU - Pandya, Nish

AU - Denham, David B.

AU - Parel, Jean Marie

AU - Robinson, David S.

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N2 - Purpose: Laser interstitial thermotherapy is a promising minimally-invasive technique for the treatment of small cancers of the breast that are currently removed surgically by lumpectomy. The purpose of this work was to analyze in-situ temperature fields recorded with stainless-steel thermocouple probes during experimental laser interstitial thermo-therapy (LITT). Methods: Both a CW Nd:YAG laser system emitting 20 W for 25 to 30s and a 980 nm diode laser emitting 10 to 20 W for up to 1200s delivered through a fiber-optic probe were used to create localized heating in fatty cadaver pig tissue and milk as phantoms. To quantify an artifact due to direct heating of the thermocouple probes by laser radiation, experiments were also performed in air, water and intralipid solution. The temperature field around the fiber-optic probe during laser irradiation was measured every 0.3 s or 1 s with an array of up to fifteen needle thermocouple probes. The effect of light absorption by the thermocouples probes was quantified and the time-dependence of the temperature distribution was analyzed. Results: After removal of the thermocouple artifact, the temperature was found to vary exponentially with time with a time constant of 600 to 700 s. Conclusions: The time-dependence of the interstitial temperature can be modeled by exponential functions both during ex vivo and in vivo experiments.

AB - Purpose: Laser interstitial thermotherapy is a promising minimally-invasive technique for the treatment of small cancers of the breast that are currently removed surgically by lumpectomy. The purpose of this work was to analyze in-situ temperature fields recorded with stainless-steel thermocouple probes during experimental laser interstitial thermo-therapy (LITT). Methods: Both a CW Nd:YAG laser system emitting 20 W for 25 to 30s and a 980 nm diode laser emitting 10 to 20 W for up to 1200s delivered through a fiber-optic probe were used to create localized heating in fatty cadaver pig tissue and milk as phantoms. To quantify an artifact due to direct heating of the thermocouple probes by laser radiation, experiments were also performed in air, water and intralipid solution. The temperature field around the fiber-optic probe during laser irradiation was measured every 0.3 s or 1 s with an array of up to fifteen needle thermocouple probes. The effect of light absorption by the thermocouples probes was quantified and the time-dependence of the temperature distribution was analyzed. Results: After removal of the thermocouple artifact, the temperature was found to vary exponentially with time with a time constant of 600 to 700 s. Conclusions: The time-dependence of the interstitial temperature can be modeled by exponential functions both during ex vivo and in vivo experiments.

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Mathematical analysis of the temperature field during ex vivo and in vivo experimental laser interstitial thermotherapy (LITT) in breast tissue models

Abstract

ASJC Scopus subject areas

UN SDGs

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